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The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3), yeast YBF2 and SAS2, and TIP60 (HTATIP). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin.
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