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Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels. Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter Syndrome. CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.
chloride channel; chloride channel K1-like; putative basolateral cTAL chloride channel ClC-Ka; chloride channel K2; chloride channel Ka; Chloride channel Kb; chloride channel protein ClC-Ka; Chloride channel protein ClC-Kb; chloride channel, kidney, B; chloride channel, voltage-sensitive Ka; chloride channel, voltage-sensitive Kb; chloride voltage-gated channel Kb; clC-K1; Clck2; ClC-K2; ClC-K2L; Clc-Ka; CLCKB; ClC-Kb; CLCNK; Clcnk1l; CLCNKA; Clcnkb; hClC-Kb; LOC100730738; MGC24087; putative basolateral mTAL chloride channel ClC-Ka; RP11-5P18.8
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