CTDSP2 is one of several small CTD phosphatases (SCP). It has been proposed that SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes. In addition, expression of phosphatase CTDSP2 mRNA isenhanced in several cancer cell lines with amplification of the CTDSP2 and CDK4 genes, and CTDSP2 coamplifies with CDK4 in some primary sarcomas. CTDSP2 may contribute to the development of a subset of sarcomas.
AI586070; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; conserved gene amplified in osteosarcoma; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; CTD small phosphatase 2; CTDSP2; D10Ertd73e; NIF2; NLI-interacting factor 2; nuclear LIM interactor-interacting factor 2; nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4); nuclear LIM interactor-interacting factor 2-like; OS4; OS-4; protein OS-4; PSR2; SCP2; small CTD phosphatase 2; Small C-terminal domain phosphatase 2
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