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This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
69 kDa islet cell autoantigen; 69kDa; diabetes mellitus type I autoantigen; ica1; ica1 {ECO:0000312; ICA69; ICAp69; Islet cell autoantigen 1; islet cell autoantigen 1 isoform; islet cell autoantigen 1, 69 kDa; islet cell autoantigen 1, 69kDa; islet cell autoantigen p69; p69; RGD:621465}; testicular tissue protein Li 162; Unknown (protein for MGC:134001); zgc:92566
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