Search Thermo Fisher Scientific
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
3110038L02Rik; BRI3; Bricd2c; BRICHOS domain containing 2C; cerebral protein 14; CT-BRI3; E25; E25C; hRPC.1050_D_4; hucep-14; Integral membrane protein 2C; integral membrane protein 3; Itm2c; ITM3; NPD018; PSEC0047; Transmembrane protein BRI3
100 µL
400 µL
50 µg