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NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3. proNGF is abundant in central nervous system tissues whereas mature NGF is undetectable, suggesting that proNGF may have a function distinct from its role as a precursor. Studies suggest that proNGF has apoptotic activity which contrast with other data demonstrating that proNGF has neurotrophic activity.
proNGF