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This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. It participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.
1500011E07Rik; AD-015; ADO15; C78786; chondroitin sulfate synthase 1; CHSY1; H4; H-4; H47; H-47; histocompatibility 47; MGC104346; MGC2553; minor histocompatibility antigen H47; SBBI8; selenoprotein S; Selenos; SELS; SEPS1; sg2; similar to selenoprotein S; Tanis; valosin-containing protein-interacting membrane protein; VCP interacting membrane selenoprotein; VCP-interacting membrane protein; VCP-interacting membrane selenoprotein; vimp; wu:fc16a03; zgc:136970
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