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TCF4 is transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG')-a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Defects in this gene are a cause of Pitt-Hopkins syndrome.
5730422P05Rik; ASP-I2; bHLHb19; class A helix-loop-helix transcription factor ME2; Class B basic helix-loop-helix protein 19; E2 2; E2.2; E2-2; FECD3; Immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; ITF 2; ITF2; ITF-2; ITF-2b; ME2; MGC149723; MGC149724; MITF-2; MITF-2A; MITF-2B; PTHS; R8f DNA-binding protein; RITF-2; SEF 2; SEF2; SEF-2; SEF2 1; SEF2 1A; SEF2 1B; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; SL3-3 enhancer factor 2; TCF 4; TCF4; TCF-4; TFE; Transcription factor 4; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform L; transcription factor 4, isoform M; transcription factor 4, isoform R
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