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TRIM22 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.
50 kDa-stimulated trans-acting factor; E3 ubiquitin-protein ligase TRIM22; GPSTAF50; RING finger protein 94; RING-type E3 ubiquitin transferase TRIM22; RNF94; STAF50; Staf-50; stimulated trans-acting factor (50 kDa); TRIM22; tripartite binding motif 22; tripartite motif containing 22; tripartite motif protein TRIM22; tripartite motif-containing 22; tripartite motif-containing protein 22
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