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E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
AI853514; HectH2; HECT-type ubiquitin transferase E3C; KIAA0010; KIAA10; mKIAA0010; RGD1559986; Ube3c; ubiquitin protein ligase E3C; ubiquitin-protein isopeptide ligase (E3); ubiquitin-protein ligase E3C
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