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Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
C330046L10Rik; deubiquitinating enzyme 49; Gm545; RGD1310513; ubiquitin carboxyl-terminal hydrolase 49; ubiquitin specific peptidase 49; ubiquitin specific protease 49; ubiquitin thioesterase 49; ubiquitin thiolesterase 49; ubiquitin-specific-processing protease 49; Usp49
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