Invitrogen

CD206 (MMR) Monoclonal Antibody (MR6F3), PE, eBioscience™

CD206 (MMR) Antibody in Flow Cytometry (Flow)

图: 1 / 65

CD206 (MMR) Antibody (12-2061-82) in Flow

Mouse resident peritoneal exudate cells were surface stained with Anti-Mouse F4/80 Antigen APC (Product # 17-4801-82) followed by fixation and permeabilization with the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00). Cells were then intracellularly stained with 0.06 µg of Rat IgG2b K Isotype Control PE (Product # 12-4031-82) (left) or 0.06 µg of Anti-Mouse CD206 (MMR) PE (right). Total cells were used for analysis.

CD206 (MMR) Antibody in Immunocytochemistry (ICC/IF)

Product Image Gallery

产品信息

12-2061-82

应用

建议稀释比

已发表文章

免疫印迹 (WB)

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

0.125 µg/test

查看58篇已发表文章 58篇已发表文章

产品规格

种属反应

Mouse

已发表种属

Human, Mouse

宿主/亚型

Rat / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

MR6F3

偶联物

PE PE PE

激发/发射光谱

565/576 nm 查看光谱

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2637422

产品详细信息

Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. CD206 belongs to the C-type lectin family. Extracellular regions of CD206 include an N-terminal cysteine-rich (CR) domain that binds sulfated glycoproteins, a fibronectin II (FNII) domain that binds collagens, and eight carbohydrate recognition domains (CRDs) that bind sugars like mannose and fucose with high affinity. CD206 mediates phagocytic and endocytic uptake of fungal, bacterial, protozoan and viral antigens, and plays an important role in immune defense and immune regulation. A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. CD206 is considered to be one of the markers of M2 macrophages. Factors inducing its expression include: IL-4, IL-13, M-CSF, IL-6, IL-10, and glucocorticoids, while TNF-alpha, IFN-gamma, TGF-beta, and LPS have been reported to down-regulate expression of CD206.

It has been demonstrated that only a small fraction of CD206 is present at the cell surface, therefore, intracellular staining is recommended.

Applications Reported: This MR6F3 antibody has been reported for use in flow cytometric analysis, and intracellular staining followed by flow cytometric analysis.

Applications Tested: This MR6F3 antibody has been tested by intracellular staining and flow cytometric analysis of mouse resident peritoneal exudate cells using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis.

Neural regeneration research

Liu C,Guo S,Liu R,Guo M,Wang Q,Chai Z,Xiao B,Ma C

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2024

TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum.

Journal of cellular and molecular medicine

Zhu D,Huang M,Shen P,Zhang B,Chen G,Chen J,Duan L,Duan Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

A pref-1-controlled non-inflammatory mechanism of insulin resistance.

iScience

Huang Y,Cui D,Chen L,Tong H,Wu H,Muller GK,Qi Y,Wang S,Xu J,Gao X,Fifield KE,Wang L,Xia Z,Vanderluit JL,Liu S,Leng L,Sun G,McGuire J,Young LH,Bucala R,Qi D

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri Jun 16 00:00:00 EDT 2023

Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects.

Bioactive materials

Li S,Zhang L,Liu C,Kim J,Su K,Chen T,Zhao L,Lu X,Zhang H,Cui Y,Cui X,Yuan F,Pan H

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2023

Hydrochlorothiazide-induced glucose metabolism disorder is mediated by the gut microbiota via LPS-TLR4-related macrophage polarization.

iScience

Luo JQ,Ren H,Chen MY,Zhao Q,Yang N,Liu Q,Gao YC,Zhou HH,Huang WH,Zhang W

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri Jul 21 00:00:00 EDT 2023

Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Zuo B,Li T,Liu X,Wang S,Cheng J,Liu X,Cui W,Shi H,Ling C

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2023

MIR222HG attenuates macrophage M2 polarization and allergic inflammation in allergic rhinitis by targeting the miR146a-5p/TRAF6/NF-κB axis.

Frontiers in immunology

Wen S,Li F,Tang Y,Dong L,He Y,Deng Y,Tao Z

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri May 26 00:00:00 EDT 2023

Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing.

Signal transduction and targeted therapy

Liu W,Chen W,Xie M,Chen C,Shao Z,Zhang Y,Zhao H,Song Q,Hu H,Xing X,Cai X,Deng X,Li X,Wang P,Liu G,Xiong L,Lv X,Zhang Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Wed Jul 05 00:00:00 EDT 2023

Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis.

Veterinary research

Feng L,Luo G,Li Y,Zhang C,Liu Y,Liu Y,Chen H,He D,Zhu Y,Gan L

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Tue Mar 14 00:00:00 EDT 2023

BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization.

NPJ Regenerative medicine

Wang J,Xue Y,Wang Y,Liu C,Hu S,Zhao H,Gu Q,Yang H,Huang L,Zhou X,Shi Q

12-2061-82 was used in Flow Cytometry to suggest that BMP2pp may be a potential option for treating prosthetic loosening induced by wear debris from prostheses.

Thu Feb 09 00:00:00 EST 2023

BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization.

NPJ Regenerative medicine

Wang J,Xue Y,Wang Y,Liu C,Hu S,Zhao H,Gu Q,Yang H,Huang L,Zhou X,Shi Q

12-2061-82 was used in Flow Cytometry to suggest that BMP2pp may be a potential option for treating prosthetic loosening induced by wear debris from prostheses.

Thu Feb 09 00:00:00 EST 2023

Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.

Materials today. Bio

Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

L-norvaline affects the proliferation of breast cancer cells based on the microbiome and metabolome analysis.

Journal of applied microbiology

Zhu Q,Zai H,Zhang K,Zhang X,Luo N,Li X,Hu Y,Wu Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2022

G9a promotes inflammation in Streptococcus pneumoniae induced pneumonia mice by stimulating M1 macrophage polarization and H3K9me2 methylation in FOXP1 promoter region.

Annals of translational medicine

Li Y,Li G,Zhang L,Li Y,Zhao Z

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2022

Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.

Cancer immunology research

Wu Q,Huang Q,Jiang Y,Sun F,Liang B,Wang J,Hu X,Sun M,Ma Z,Shi Y,Liang Y,Tan Y,Zeng D,Yao F,Xu X,Yao Z,Li S,Rong X,Huang N,Sun L,Liao W,Shi M

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Tue Feb 01 00:00:00 EST 2022

Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy.

JCI insight

Howard ZM,Gomatam CK,Rabolli CP,Lowe J,Piepho AB,Bansal SS,Accornero F,Rafael-Fortney JA

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Oct 10 00:00:00 EDT 2022

Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.

Journal of nanobiotechnology

Li K,Yan G,Huang H,Zheng M,Ma K,Cui X,Lu D,Zheng L,Zhu B,Cheng J,Zhao J

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Thu Jan 20 00:00:00 EST 2022

TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target.

Biology

Palacios LM,Peyret V,Viano ME,Geysels RC,Chocobar YA,Volpini X,Pellizas CG,Nicola JP,Motran CC,Rodriguez-Galan MC,Fozzatti L

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Thu Nov 03 00:00:00 EDT 2022

EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis.

Cell death & disease

Zhang X,Chen C,Ling C,Luo S,Xiong Z,Liu X,Liao C,Xie P,Liu Y,Zhang L,Chen Z,Liu Z,Tang J

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Nov 07 00:00:00 EST 2022

Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.

International journal of biological sciences

Qian Z,Chen H,Xia M,Chang J,Li X,Ye S,Wu S,Jiang S,Bao J,Wang B,Kong R,Zhang S,Zheng S,Cao X,Hong X

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri Apr 15 00:00:00 EDT 2022

Local and systemic inflammation triggers different outcomes of tumor growth related to infiltration of anti-tumor or pro-tumor macrophages.

Chinese medical journal

Liu X,Jiang Q,Shen S,Hou Y

12-2061-82 was used in Flow cytometry/Cell sorting to suggest that the different outcomes of tumor growth might be attributed to the infiltration of anti-tumor or pro-tumor immune cells, especially M1 or M2 type macrophages into tumor microenvironment.

Fri Aug 05 00:00:00 EDT 2022

The cephalic phase of insulin release is modulated by IL-1β.

Cell metabolism

Wiedemann SJ,Trimigliozzi K,Dror E,Meier DT,Molina-Tijeras JA,Rachid L,Le Foll C,Magnan C,Schulze F,Stawiski M,Häuselmann SP,Méreau H,Böni-Schnetzler M,Donath MY

12-2061-82 was used in Flow cytometry/Cell sorting to describe that this incretin-like effect of IL-1β involves neuronal transmission.

Tue Jul 05 00:00:00 EDT 2022

Anti-CD52 antibody treatment in murine experimental autoimmune encephalomyelitis induces dynamic and differential modulation of innate immune cells in peripheral immune and central nervous systems.

Immunology

Barbour M,Wood R,Harte T,Bushell TJ,Jiang HR

12-2061-82 was used in Flow Cytometry to support the CNS-specific beneficial effect of alemtuzumab treatment on inhibiting neuroinflammation in multiple sclerosis patients.

Tue Mar 01 00:00:00 EST 2022

A Novel Selective Axl/Mer/CSF1R Kinase Inhibitor as a Cancer Immunotherapeutic Agent Targeting Both Immune and Tumor Cells in the Tumor Microenvironment.

Cancers

Jeon Y,Kang H,Yang Y,Park D,Choi B,Kim J,Kim J,Nam K

12-2061-82 was used in Flow Cytometry to present Q702, a selective, potent small molecule inhibitor targeting Axl, Mer, and CSF1R, for oral administration.

Sun Oct 02 00:00:00 EDT 2022

Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors.

Theranostics

Cao S,Hung YW,Wang YC,Chung Y,Qi Y,Ouyang C,Zhong X,Hu W,Coblentz A,Maghami E,Sun Z,Lin HH,Ann DK

12-2061-82 was used in Flow cytometry/Cell sorting to determine if attenuated host autophagy is sufficient to induce tumor rejection through reinforced adaptive immunity and whether dietary glutamine supplementation, mimicking attenuated host autophagy, is capable of promoting antitumor immunity.

Tue Aug 16 00:00:00 EDT 2022

Pirfenidone modulates macrophage polarization and ameliorates radiation-induced lung fibrosis by inhibiting the TGF-β1/Smad3 pathway.

Journal of cellular and molecular medicine

Ying H,Fang M,Hang QQ,Chen Y,Qian X,Chen M

12-2061-82 was used in Flow cytometry/Cell sorting to investigate the use of pirfenidone in treating radiation-induced lung injury in mouse models.

Wed Sep 01 00:00:00 EDT 2021

Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization.

Stem cell research & therapy

Dong B,Wang C,Zhang J,Zhang J,Gu Y,Guo X,Zuo X,Pan H,Hsu AC,Wang G,Wang F

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Wed Mar 24 00:00:00 EDT 2021

Hyperoside Suppresses Renal Inflammation by Regulating Macrophage Polarization in Mice With Type 2 Diabetes Mellitus.

Frontiers in immunology

Liu J,Zhang Y,Sheng H,Liang C,Liu H,Moran Guerrero JA,Lu Z,Mao W,Dai Z,Liu X,Zhang L

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Thu Feb 10 00:00:00 EST 2022

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.

Cells

Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Nov 15 00:00:00 EST 2021

Azithromycin alleviates systemic lupus erythematosus via the promotion of M2 polarisation in lupus mice.

Cell death discovery

Wang J,Chen Q,Zhang Z,Wang S,Wang Y,Xiang M,Liang J,Xu J

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri Apr 16 00:00:00 EDT 2021

Resolving macrophage polarization through distinct Ca²⁺ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.

iScience

Nascimento Da Conceicao V,Sun Y,Ramachandran K,Chauhan A,Raveendran A,Venkatesan M,DeKumar B,Maity S,Vishnu N,Kotsakis GA,Worley PF,Gill DL,Mishra BB,Madesh M,Singh BB

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri Nov 19 00:00:00 EST 2021

Thymopentin treatment of murine premature ovarian failure via attenuation of immune cell activity and promotion of the BMP4/Smad9 signalling pathway.

International journal of medical sciences

Zhu X,Liu J,Pan H,Geng Z,Huang W,Liu T,Zhang B

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Immunocytochemistry

Tue Mar 15 00:00:00 EDT 2022

Thymopentin treatment of murine premature ovarian failure via attenuation of immune cell activity and promotion of the BMP4/Smad9 signalling pathway.

International journal of medical sciences

Zhu X,Liu J,Pan H,Geng Z,Huang W,Liu T,Zhang B

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Immunocytochemistry

Tue Mar 15 00:00:00 EDT 2022

Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice.

Frontiers in pharmacology

Han H,Peng G,Meister M,Yao H,Yang JJ,Zou MH,Liu ZR,Ji X

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Sat Apr 02 00:00:00 EDT 2022

Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis.

Stem cell research & therapy

Wang F,Kong L,Wang W,Shi L,Wang M,Chai Y,Xu J,Kang Q

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Thu May 13 00:00:00 EDT 2021

PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway.

Frontiers in immunology

Kong F,Sun K,Zhu J,Li F,Lin F,Sun X,Luo X,Ren C,Lu L,Zhao S,Sun J,Wang Y,Shi J

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Nov 01 00:00:00 EDT 2021

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice.

Communications biology

Song L,Chang R,Sun X,Lu L,Gao H,Lu H,Lin R,Xu X,Liu Z,Zhan L

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Tue Feb 16 00:00:00 EST 2021

BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions.

Cell death & disease

Zhang D,Huang J,Wang F,Ding H,Cui Y,Yang Y,Xu J,Luo H,Gao Y,Pan L,Wu Y,Gong Y,Xie L,Liu Z,Qu Y,Zhang L,Liu W,Zhang W,Zhao S,Yi Q,Niu T,Zheng Y

12-2061-82 was used in Flow Cytometry to demonstrate the role of the polycomb-group protein, BMI1, in the modulation of pro-myeloma macrophages.

Sat May 15 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

12-2061 was used in Flow cytometry/Cell sorting to presents a multifunctional metal-phenolic nanoplatform for efficient X-ray mediated RT-RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment.

Mon Feb 01 00:00:00 EST 2021

Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus.

Journal of neuroinflammation

Chen KE,Lainez NM,Nair MG,Coss D

12-2061-82 was used in Flow Cytometry to demonstrate a new connection between the adipose tissue and the hypothalamus in obesity that contributes to neuroinflammation and hypothalamic pathologies.

Mon Jun 21 00:00:00 EDT 2021

Requirement of direct contact between chondrocytes and macrophages for the maturation of regenerative cartilage.

Scientific reports

Kanda K,Asawa Y,Inaki R,Fujihara Y,Hoshi K,Hikita A

12-2061-82 was used in Flow Cytometry to provide insights for establishing a method of in vitro cartilage regeneration.

Thu Nov 18 00:00:00 EST 2021

Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype.

International journal of medical sciences

Liu X,Xu Y,Li Y,Pan Y,Zhao S,Hou Y

12-2061-82 was used in Flow cytometry/Cell sorting to create a nanocomposite of Ferumoxytol (FMT) surface-coated with β-glucan (FMT-β-glucan), which effectively suppressed melanoma growth by promoting the polarization of M1 macrophages in the tumor microenvironment, enhancing the antitumor effect both in vivo and in vitro, likely through the upregulation of Dectin-1 and activation of MAPK and NF-κB signaling pathways in macrophages.

Mon Jan 10 00:00:00 EST 2022

The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ.

Experimental & molecular medicine

Lee YS,Song SJ,Hong HK,Oh BY,Lee WY,Cho YB

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ.

Experimental & molecular medicine

Lee YS,Song SJ,Hong HK,Oh BY,Lee WY,Cho YB

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Macrophage polarization plays roles in bone formation instructed by calcium phosphate ceramics.

Journal of materials chemistry. B

Li M,Guo X,Qi W,Wu Z,de Bruijn JD,Xiao Y,Bao C,Yuan H

12-2061 was used in Flow cytometry/Cell sorting to investigate the roles of macrophages in material-instructed bone formation.

Wed Mar 04 00:00:00 EST 2020

Mesenchymal stem cell-secreted extracellular vesicles carrying TGF-β1 up-regulate miR-132 and promote mouse M2 macrophage polarization.

Journal of cellular and molecular medicine

Wang Y,Han B,Wang Y,Wang C,Zhang H,Xue J,Wang X,Niu T,Niu Z,Chen Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

Mesenchymal stem cell-secreted extracellular vesicles carrying TGF-β1 up-regulate miR-132 and promote mouse M2 macrophage polarization.

Journal of cellular and molecular medicine

Wang Y,Han B,Wang Y,Wang C,Zhang H,Xue J,Wang X,Niu T,Niu Z,Chen Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.

Nature communications

Chen J,Wang L,Xu H,Xing L,Zhuang Z,Zheng Y,Li X,Wang C,Chen S,Guo Z,Liang Q,Wang Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Jun 22 00:00:00 EDT 2020

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.

Nature communications

Chen J,Wang L,Xu H,Xing L,Zhuang Z,Zheng Y,Li X,Wang C,Chen S,Guo Z,Liang Q,Wang Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Jun 22 00:00:00 EDT 2020

Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury.

Journal of neuroinflammation

Kong FQ,Zhao SJ,Sun P,Liu H,Jie J,Xu T,Xu AD,Yang YQ,Zhu Y,Chen J,Zhou Z,Qian DF,Gu CJ,Chen Q,Yin GY,Zhang HW,Fan J

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Mon Feb 17 00:00:00 EST 2020

Mesenchymal stem cells reduce alcoholic hepatitis in mice via suppression of hepatic neutrophil and macrophage infiltration, and of oxidative stress.

PloS one

Wan YM,Li ZQ,Liu C,He YF,Wang MJ,Wu XN,Zhang Y,Li YH

12-2061-82 was used in Flow Cytometry to investigate whether MSCs are effective in treating mice with alcoholic hepatitis (AH) and its underlying mechanism.

Thu May 07 00:00:00 EDT 2020

Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.

JCI insight

Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY

12-2061 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.

Thu Jun 18 00:00:00 EDT 2020

Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.

Cancer immunology research

Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR

12-2061 was used in Flow cytometry/Cell sorting to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.

Mon Apr 01 00:00:00 EDT 2019

Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models.

Breast cancer research : BCR

Sabol RA,Bowles AC,Côté A,Wise R,O'Donnell B,Matossian MD,Hossain FM,Burks HE,Del Valle L,Miele L,Collins-Burow BM,Burow ME,Bunnell BA

12-2061 was used in Flow cytometry/Cell sorting to study the mechanisms by which obesity promotes tumour progression.

Wed May 22 00:00:00 EDT 2019

Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

CNS neuroscience & therapeutics

Peng J,Wang K,Xiang W,Li Y,Hao Y,Guan Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1.

Frontiers in endocrinology

Loiola RA,Wickstead ES,Solito E,McArthur S

12-2061-82 was used in Flow Cytometry to investigate the role of estrogen following brain tissue injury.

Tue Feb 25 00:00:00 EST 2020

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.

Journal for immunotherapy of cancer

Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 12-2061-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model.

Translational neurodegeneration

Costa-Marques L,Arnold K,Pardon MC,Leovsky C,Swarbrick S,Fabian C,Stolzing A

12-2061-82 was used in Flow cytometry/Cell sorting to investigate early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages in APP/PS1 transgenic mice.