Product References
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using IgD monoclonal antibody (Product # 12-5993-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Journal of immunology (Baltimore, Md. : 1950)
Bonami RH,Nyhoff LE,McNitt DH,Hulbert C,Felton JL,Kendall PL,Thomas JW
12-5993-82 was used in Flow Cytometry to understand how fully developed T follicular helper cells contribute to different autoimmune processes, investigating the role of signaling lymphocytic activation molecule-associated protein in type 1 diabetes and autoantibody-mediated arthritis.
Tue Dec 15 00:00:00 EST 2020
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
Nature
Ghezraoui H,Oliveira C,Becker JR,Bilham K,Moralli D,Anzilotti C,Fischer R,Deobagkar-Lele M,Sanchiz-Calvo M,Fueyo-Marcos E,Bonham S,Kessler BM,Rottenberg S,Cornall RJ,Green CM,Chapman JR
12-5993 was used in Flow cytometry/Cell sorting to conclude that the 53BP1 pathway therefore comprises distinct double-strand break repair activities within chromatin and single-stranded DNA compartments, which explains both the immunological differences between 53bp1- and Rev7- deficient mice and the context specificity of the pathway.
Wed Aug 01 00:00:00 EDT 2018
IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
eLife
Noviski M,Mueller JL,Satterthwaite A,Garrett-Sinha LA,Brombacher F,Zikherman J
12-5993-82 was used in Flow Cytometry to study how IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
Fri Mar 09 00:00:00 EST 2018
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Oncogene
Sochalska M,Schuler F,Weiss JG,Prchal-Murphy M,Sexl V,Villunger A
12-5993 was used in Flow cytometry/Cell sorting to analyse the role of the anti-apoptotic protein, BCL2A1/A1, in blood cancers driven by either the MYC or ABL kinases.
Sat Apr 01 00:00:00 EDT 2017
Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses.
PeerJ
Early M,Schroeder WG,Unnithan R,Gilchrist JM,Muller WA,Schenkel A
12-5993 was used in Flow cytometry/Cell sorting to examine the role of PECAM-1 in the migration capacity of several different leukocyte populations after primary and secondary application.
Mon Dec 14 00:00:00 EST 2020
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
12-5993 was used in Flow cytometry/Cell sorting to support that Stat3- and BCL6-dependent extrafollicular CD4+ T and B interactions play critical functions in the pathogenesis of chronic graft-versus-host disease.
Tue Oct 17 00:00:00 EDT 2017
Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria.
Mucosal immunology
Rios D,Wood MB,Li J,Chassaing B,Gewirtz AT,Williams IR
12-5993 was used in Immunofluorescence to demonstrate that M-cell-mediated sampling of commensal bacteria is a required initial step for efficient induction of intestinal SIgA.
Fri Jul 01 00:00:00 EDT 2016
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Hilpert C,Sitte S,Matthies A,Voehringer D
12-5993 was used in Immunohistochemistry-immunofluorescence to study the role of dendritic cells as antigen presenting cells and a source of type I interferons in acute lymphocytic choriomeningitis virus infection.
Sat Oct 01 00:00:00 EDT 2016
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
Nature communications
Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C
12-5993 was used in Flow cytometry/Cell sorting to examine the regulation B-cell development and tolerance by different members of the miR-17~92 family microRNAs.
Tue Aug 02 00:00:00 EDT 2016
Distinct germinal center selection at local sites shapes memory B cell response to viral escape.
The Journal of experimental medicine
Adachi Y,Onodera T,Yamada Y,Daio R,Tsuiji M,Inoue T,Kobayashi K,Kurosaki T,Ato M,Takahashi Y
12-5993 was used in Flow cytometry/Cell sorting to investigate the cellular events dictating the cross-reactive memory B cell responses, showing that distinct germinal center selection at local sites shapes response to viral escape.
Mon Sep 21 00:00:00 EDT 2015
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
12-5993 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using IgD monoclonal antibody (Product # 12-5993-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Germinal center reaction following cutaneous dengue virus infection in immune-competent mice.
Frontiers in immunology
Yam-Puc JC,García-Cordero J,Calderón-Amador J,Donis-Maturano L,Cedillo-Barrón L,Flores-Romo L
12-5993 was used in Flow cytometry/Cell sorting to investigate the involvement of GC reactions in a model of cutaneous dengue virus infection, and whether preferential antibody responses occur.
Tue May 12 00:00:00 EDT 2015
Core fucosylation of IgG B cell receptor is required for antigen recognition and antibody production.
Journal of immunology (Baltimore, Md. : 1950)
Li W,Yu R,Ma B,Yang Y,Jiao X,Liu Y,Cao H,Dong W,Liu L,Ma K,Fukuda T,Liu Q,Ma T,Wang Z,Gu J,Zhang J,Taniguchi N
12-5993 was used in Flow cytometry/Cell sorting to investigate core fucosylation of IgG B cell receptor's role in antigen recognition and antibody production.
Sun Mar 15 00:00:00 EDT 2015
BILL-cadherin/cadherin-17 contributes to the survival of memory B cells.
PloS one
Funakoshi S,Shimizu T,Numata O,Ato M,Melchers F,Ohnishi K
Published figure using IgD monoclonal antibody (Product # 12-5993-82) in Flow Cytometry
Wed Sep 16 00:00:00 EDT 2015
The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.
PloS one
Vettermann C,Timblin GA,Lim V,Lai EC,Schlissel MS
12-5993 was used in Flow cytometry/Cell sorting to identify the proximal GT promoter as the first cis-element known to regulate the internal order of Jκ rearrangements.
Tue Jan 26 00:00:00 EST 2016
IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Visekruna A,Papoutsopoulou S,Janzen J,Zillwood R,Tarlinton DM,Tybulewicz VL,Ley SC
12-5993 was used in Immunohistochemistry to assess the importance of IκB kinase (IKK)-induced proteolysis of NF-κB1 p105 in B cells on immune responses.
Mon Sep 22 00:00:00 EDT 2014
IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Visekruna A,Papoutsopoulou S,Janzen J,Zillwood R,Tarlinton DM,Tybulewicz VL,Ley SC
12-5993 was used in Immunohistochemistry to assess the importance of IκB kinase (IKK)-induced proteolysis of NF-κB1 p105 in B cells on immune responses.
Mon Sep 22 00:00:00 EDT 2014
Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells and is associated with alterations in the kidney plasma cell niche.
Journal of immunology (Baltimore, Md. : 1950)
Wang W,Rangel-Moreno J,Owen T,Barnard J,Nevarez S,Ichikawa HT,Anolik JH
12-5993 was used in Immunofluorescence to suggest that prolonged B-cell depletion may alter the PC survival niche in the kidney.
Tue Apr 01 00:00:00 EDT 2014
Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin.
European journal of immunology
Todd EM,Deady LE,Morley SC
12-5993 was used in Flow cytometry/Cell sorting to study the role of L-plastin in the modulation of both T- and B-cell immune responses.
Mon Jul 01 00:00:00 EDT 2013
Loss of an Igκ gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation.
Molecular and cellular biology
Zhou X,Xiang Y,Ding X,Garrard WT
Published figure using IgD monoclonal antibody (Product # 12-5993-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2013
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.
PloS one
Billich A,Baumruker T,Beerli C,Bigaud M,Bruns C,Calzascia T,Isken A,Kinzel B,Loetscher E,Metzler B,Mueller M,Nuesslein-Hildesheim B,Kleylein-Sohn B
12-5993 was used in Flow cytometry/Cell sorting to investigate the involvement of Sgpl1 in models of disease, showing that partial deficiency confers protection in EAE.
Tue Sep 17 00:00:00 EDT 2013
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
12-5993-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
12-5993 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 EST 2012
Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction.
Immunity
Tezuka H,Abe Y,Asano J,Sato T,Liu J,Iwata M,Ohteki T
12-5993 was used in Immunohistochemistry to investigate the molecular basis of pDC conditioning to induce mucosal TI IgA production, which may lead to improvements in vaccination strategies and treatment for mucosal-related disorders.
Fri Feb 25 00:00:00 EST 2011
Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.
The Journal of experimental medicine
Ota T,Ota M,Duong BH,Gavin AL,Nemazee D
12-5993 was used in Flow cytometry/Cell sorting to postulate that clonal deletion is the major irreversible pathway of tolerance induction among peripheral B cells.
Mon Mar 14 00:00:00 EDT 2011
Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.
Journal of virology
Santiago ML,Smith DS,Barrett BS,Montano M,Benitez RL,Pelanda R,Hasenkrug KJ,Greene WC
12-5993 was used in Flow cytometry/Cell sorting to argue against the generality of BAFF-R polymorphisms as a dominant mechanism to explain the Rfv3 recovery phenotype and further strengthen the evidence that Apobec3 encodes Rfv3.
Sat Jan 01 00:00:00 EST 2011
The actin-bundling protein L-plastin is essential for marginal zone B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Todd EM,Deady LE,Morley SC
12-5993 was used in Flow cytometry/Cell sorting to study the role of the actin-bundling protein L-plastin in B cell chemotaxis.
Thu Sep 15 00:00:00 EDT 2011
CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch.
International immunology
Ebisawa M,Hase K,Takahashi D,Kitamura H,Knoop KA,Williams IR,Ohno H
12-5993 was used in Flow cytometry/Cell sorting to suggest that the spatial regulation of CCR6(hi)CD11c(int) B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation.
Fri Apr 01 00:00:00 EDT 2011
Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aït-Azzouzene D,Aoki-Ota M,Vela JL,Huber C,Walsh K,Gavin AL,Nemazee D
12-5993 was used in Flow cytometry/Cell sorting to generate mice which ubiquitously expressed a membrane-bound IgD-superantigen, to provide a model which should facilitate studies of peripheral B cell tolerance in future.
Thu Apr 15 00:00:00 EDT 2010
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation.
Nature immunology
Wilker PR,Kohyama M,Sandau MM,Albring JC,Nakagawa O,Schwarz JJ,Murphy KM
12-5993 was used in Flow cytometry/Cell sorting to emphasise an unrecognised but critical function for Mef2c in BCR signalling.
Sun Jun 01 00:00:00 EDT 2008
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
Proceedings of the National Academy of Sciences of the United States of America
Kikuchi K,Kondo M
12-5993 was used in Flow cytometry/Cell sorting to demonstrate how foetal haematopoietic stem cells may acquire adult characteristics between 1 and 2 weeks after birth in mouse bone marrow.
Tue Nov 21 00:00:00 EST 2006
