Product References
BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer.
Journal of translational medicine
Li W,Zhao C,Li W,Gong Y,Ma K,Lu Y,Liu X,Zhang L,Guo F
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Wed Oct 18 00:00:00 EDT 2023
Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine.
Cell reports. Medicine
Dan J,Cai J,Zhong Y,Wang C,Huang S,Zeng Y,Fan Z,Xu C,Hu L,Zhang J,Hu J,Liu Y,Su X,Zhu W,Yan G,Liang J,Lin Y
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2023
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion.
iScience
Ma K,Sun L,Shen M,Zhang X,Xiao Z,Wang J,Liu X,Jiang K,Xiao-Feng Qin F,Guo F,Zhang B,Zhang L
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Fri May 20 00:00:00 EDT 2022
M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway.
Cell death discovery
Pu J,Xu Z,Nian J,Fang Q,Yang M,Huang Y,Li W,Ge B,Wang J,Wei H
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Fri Jul 16 00:00:00 EDT 2021
Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression.
Journal for immunotherapy of cancer
Pierini S,Mishra A,Perales-Linares R,Uribe-Herranz M,Beghi S,Giglio A,Pustylnikov S,Costabile F,Rafail S,Amici A,Facciponte JG,Koumenis C,Facciabene A
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Anti-PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Rao G,Latha K,Ott M,Sabbagh A,Marisetty A,Ling X,Zamler D,Doucette TA,Yang Y,Kong LY,Wei J,Fuller GN,Benavides F,Sonabend AM,Long J,Li S,Curran M,Heimberger AB
14-9981-82 was used in Cytotoxicity assay to show that the therapeutic effect of anti-PD-1 blockade in GBM may be mediated by the innate immune system, rather than by CD8 T cells.
Tue Sep 01 00:00:00 EDT 2020
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Thu Aug 20 00:00:00 EDT 2020
Creatine uptake regulates CD8 T cell antitumor immunity.
The Journal of experimental medicine
Di Biase S,Ma X,Wang X,Yu J,Wang YC,Smith DJ,Zhou Y,Li Z,Kim YJ,Clarke N,To A,Yang L
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Mon Dec 02 00:00:00 EST 2019
T-cell-dependent mechanisms promote Ebola VLP-induced antibody responses, but are dispensable for vaccine-mediated protection.
Emerging microbes & infections
Cooper CL,Martins KA,Stronsky SM,Langan DP,Steffens J,Van Tongeren S,Bavari S
14-9981 was used in Flow cytometry/Cell sorting to demonstrate that humoral responses are generated through follicular B-cell and T-cell-dependent mechanisms in mouse model EBOV infection, proving how valuable the future development of additional EBOV vaccine candidates is.
Wed Jun 07 00:00:00 EDT 2017
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
The Journal of clinical investigation
Starobinets H,Ye J,Broz M,Barry K,Goldsmith J,Marsh T,Rostker F,Krummel M,Debnath J
14998182 was used in flow cytometry to test how inhibiting autophagy impacts antitumor immune responses in immune-competent mouse models of melanoma and mammary cancer
Thu Dec 01 00:00:00 EST 2016
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
Journal of immunology (Baltimore, Md. : 1950)
Harakal J,Rival C,Qiao H,Tung KS
14-9981-82 was used in Flow Cytometry to suggest that Tregs maintain physiological tolerance to clinically relevant gastric autoantigens, and Th2 responses can be a pathogenic mechanism in AIG.
Fri Jul 01 00:00:00 EDT 2016
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9981-82) in Flow Cytometry
Mon Aug 08 00:00:00 EDT 2016
A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection.
PloS one
Fontana MF,Baccarella A,Craft JF,Boyle MJ,McIntyre TI,Wood MD,Thorn KS,Anidi C,Bayat A,Chung MR,Hamburger R,Kim CY,Pearman E,Pham J,Tang JJ,Boon L,Kamya MR,Dorsey G,Feeney ME,Kim CC
14-9981 was used in Flow cytometry/Cell sorting to investigate aspects of the human immune response to asymptomatic persistent Plasmodium infection using a novel animal model.
Wed Aug 02 00:00:00 EDT 2017
Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Dai M,Yip YY,Hellstrom I,Hellstrom KE
14998182 was used in flow cytometry to test the efficacy of combining different monoclonal antibodies to treat cancer
Sun Mar 01 00:00:00 EST 2015
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.
PLoS pathogens
Pascutti MF,Geerman S,Slot E,van Gisbergen KP,Boon L,Arens R,van Lier RA,Wolkers MC,Nolte MA
14-9981 was used in Flow cytometry/Cell sorting to study resolution of chronic viral infection through GITR-mediated co-stimulation enhancing CD8 T cell responses.
Sun Mar 01 00:00:00 EST 2015
Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.
European journal of immunology
McAlees JW,Lajoie S,Dienger K,Sproles AA,Richgels PK,Yang Y,Khodoun M,Azuma M,Yagita H,Fulkerson PC,Wills-Karp M,Lewkowich IP
14-9981 was used in Flow cytometry/Cell sorting to investigate the role of PD-1 family members in allergic asthma, showing differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis.
Wed Apr 01 00:00:00 EDT 2015
Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease.
Annals of hematology
Shao L,Lie AK,Zhang Y,Wong CH,Kwong YL
14998182 was used in flow cytometry to explore the roles of T and B cells in chronic graft-versus-host disease
Tue Sep 01 00:00:00 EDT 2015
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
14-9981 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 EDT 2015
Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction.
Blood
Rosborough BR,Raïch-Regué D,Matta BM,Lee K,Gan B,DePinho RA,Hackstein H,Boothby M,Turnquist HR,Thomson AW
14-9981 was used in Functional assays to identify the first known rapamycin-insensitive mTOR pathway that is not mediated solely by mTORC2 and has implications for the use of catalytic mTOR inhibitors in inflammatory disease settings.
Thu May 02 00:00:00 EDT 2013
IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis.
Journal of neuroimmunology
Phares TW,DiSano KD,Hinton DR,Hwang M,Zajac AJ,Stohlman SA,Bergmann CC
14-9981 was used in Flow cytometry/Cell sorting to demonstrate the role of IL-21 in regulating CNS immunity.
Tue Oct 15 00:00:00 EDT 2013
PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.
Journal of neuroinflammation
Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H
14-9981 was used in Flow cytometry/Cell sorting to suggest that agents (for example antibodies) that can target and neutralise PD-L1/2 may have therapeutic potential for treatment of human stroke.
Mon Sep 09 00:00:00 EDT 2013
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-9981 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion.
Journal of immunology (Baltimore, Md. : 1950)
Wilson JJ,Pack CD,Lin E,Frost EL,Albrecht JA,Hadley A,Hofstetter AR,Tevethia SS,Schell TD,Lukacher AE
14-9981 was used in Flow cytometry/Cell sorting to characterise virus-specific CD8 T cells recruited during persistent infection.
Tue May 01 00:00:00 EDT 2012
Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.
Journal of neuroinflammation
Phares TW,Stohlman SA,Hinton DR,Bergmann CC
14-9981 was used in Flow cytometry/Cell sorting to study the biological effects of altered T-cell responses and how they were evaluated by analysis of viral control and spinal-cord pathology.
Fri Dec 14 00:00:00 EST 2012
Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment.
Journal of autoimmunity
Van Belle TL,Juntti T,Liao J,von Herrath MG
14-9981 was used in Flow cytometry/Cell sorting to investigate how Flt3 stimulation actually accelerates autoimmunity when autoreactive CD8 T cells are detectable in blood prior to treatment.
Tue Jun 01 00:00:00 EDT 2010
Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion.
Journal of virology
Blackburn SD,Crawford A,Shin H,Polley A,Freeman GJ,Wherry EJ
14-9981 was used in Flow cytometry/Cell sorting to determine how the amount of PD-1 expressed, and the anatomical location, influenced the function of exhausted CD8 T cells.
Mon Feb 01 00:00:00 EST 2010
GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
van Olffen RW,Koning N,van Gisbergen KP,Wensveen FM,Hoek RM,Boon L,Hamann J,van Lier RA,Nolte MA
14-9981 was used in Flow cytometry/Cell sorting to study the role of glucocorticoid-induced TNF receptor family-related protein on activated and regulatory T cells.
Mon Jun 15 00:00:00 EDT 2009
