Product References
Mucosal Vaccination with Live Attenuated Bordetella bronchiseptica Protects against Challenge in Wistar Rats.
Vaccines
Chamorro BM,Luca K,Swaminathan G,Rochereau N,Majorel J,Poulet H,Chanut B,Piney L,Mundt E,Paul S
17-7177-81 was used in Flow cytometry/Cell sorting to highlight the advantages of a rat model as a tool for studying candidate vaccines and routes of administration for dogs.
Mon May 15 00:00:00 EDT 2023
The Potential of Dendritic-Cell-Based Vaccines to Modulate Type 3 Innate Lymphoid Cell Populations.
International journal of molecular sciences
Chan L,Mehrani Y,Minott JA,Bridle BW,Karimi K
17-7177-81 was used in Flow cytometry/Cell sorting to explore the communications between type 3 ILCs (ILC3s) and DCs using a murine model of DC-based vaccination.
Thu Jan 26 00:00:00 EST 2023
Determination of Interleukin-17A and Interferon-γ Production in γδ, CD4+, and CD8+ T Cells Isolated from Murine Lymphoid Organs, Perivascular Adipose Tissue, Kidney, and Lung.
Bio-protocol
Comeau K,Caillon A,Paradis P,Schiffrin EL
17-7177-81 was used in Immunocytochemistry to describe a protocol to obtain single-cell suspensions from the spleen, mesenteric lymph nodes, mesenteric vessels and PVAT, lungs, and kidneys, and profile IL-17A- and IFNγ-producing T cells using flow cytometry.
Sat May 20 00:00:00 EDT 2023
Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation.
The Journal of clinical investigation
Failer T,Amponsah-Offeh M,Neuwirth A,Kourtzelis I,Subramanian P,Mirtschink P,Peitzsch M,Matschke K,Tugtekin SM,Kajikawa T,Li X,Steglich A,Gembardt F,Wegner AC,Hugo C,Hajishengallis G,Chavakis T,Deussen A,Todorov V,Kopaliani I
17-7177-81 was used in Flow Cytometry to identify DEL-1 as a potential therapeutic factor.
Tue Mar 15 00:00:00 EDT 2022
Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2.
Nature communications
Wilson AS,Randall KL,Pettitt JA,Ellyard JI,Blumenthal A,Enders A,Quah BJ,Bopp T,Parish CR,Brüstle A
17-7177-81 was used in Flow Cytometry to show that neutrophil extracellular traps, web-like DNA structures which are extruded from neutrophils upon activation, through their protein component histones, directly activate T cells and specifically enhance Th17 cell differentiation.
Wed Jan 26 00:00:00 EST 2022
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine.
Nature biomedical engineering
Wang Z,Popowski KD,Zhu D,de Juan Abad BL,Wang X,Liu M,Lutz H,De Naeyer N,DeMarco CT,Denny TN,Dinh PC,Li Z,Cheng K
17-7177-81 was used in Flow cytometry/Cell sorting to report the design and preclinical testing of an inhalable virus-like-particle as a COVID-19 vaccine that, after lyophilisation, is stable at room temperature for over three months.
Fri Jul 01 00:00:00 EDT 2022
Intestinal dysbacteriosis-propelled T helper 17 cells activation mediate the perioperative neurocognitive disorder induced by anesthesia/surgery in aged rats.
Neuroscience letters
Wen Y,Feng S,Dai H,Mao M,Zhou Z,Li B,Wang C,Cai X,Li S,Yang J,Ren Q,Sun J
17-7177-81 was used in flow cytometry to suggest that intestinal dysbacteriosis-propelled T helper 17 cells activation and IL17 secretion might play an important role in the pathogenesis of PND induced by anesthesia/surgery in aged rats.
Wed Jul 13 00:00:00 EDT 2022
Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
Cellular and molecular gastroenterology and hepatology
Abdelnabi MN,Flores Molina M,Soucy G,Quoc-Huy Trinh V,Bédard N,Mazouz S,Jouvet N,Dion J,Tran S,Bilodeau M,Estall JL,Shoukry NH
17-7177-81 was used in Flow cytometry/Cell sorting to suggest a sex-dependent hepatoprotective antiapoptotic effect of IL22-receptor signaling during NAFLD-related liver injury in females.
Tue Nov 22 00:00:00 EST 2022
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability.
Mucosal immunology
Ninnemann J,Winsauer C,Bondareva M,Kühl AA,Lozza L,Durek P,Lissner D,Siegmund B,Kaufmann SHE,Mashreghi MF,Nedospasov SA,Kruglov AA
17-7177-81 was used in Flow cytometry/Cell sorting to show how anti-TNF therapy induces mucosal healing by increasing IL-22 availability and implicates new therapeutic opportunities for IBD.
Fri Apr 01 00:00:00 EDT 2022
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Zhang Y,Li F,Chen C,Li Y,Xie W,Huang D,Zhai X,Yu W,Wan J,Li P
17-7177-81 was used in Flow cytometry/Cell sorting to show that sRAGE can serve as a novel immunometabolic modulator that ameliorates ischemic stroke recovery by inhibiting fatty acid synthesis and thus favoring CD4+ T cells polarization toward Treg after cerebral ischemia injury.
Wed Jun 01 00:00:00 EDT 2022
Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans.
Nature communications
Cao C,Wang K,Wang Y,Liu TB,Rivera A,Xue C
17-7177-81 was used in Cell Culture to show that Gpa1 is activated through phosphorylation by a CDK-related kinase (Crk1), which is targeted for degradation by an E3 ubiquitin ligase (Fbp1).
Thu Oct 27 00:00:00 EDT 2022
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells.
The Journal of clinical investigation
Yu M,Pal S,Paterson CW,Li JY,Tyagi AM,Adams J,Coopersmith CM,Weitzmann MN,Pacifici R
17-7177-81 was used in Flow Cytometry to investigate the origin of bone marrow Th17 cells and TNF+ T cells.
Mon Feb 15 00:00:00 EST 2021
Multifaceted modes of action of the anticancer probiotic Enterococcus hirae.
Cell death and differentiation
Goubet AG,Wheeler R,Fluckiger A,Qu B,Lemaître F,Iribarren K,Mondragón L,Tidjani Alou M,Pizzato E,Durand S,Derosa L,Aprahamian F,Bossut N,Moya-Nilges M,Derrien D,Chen G,Leduc M,Joseph A,Pons N,Le Chatelier E,Segata N,Yonekura S,Iebba V,Kepp O,Raoult D,André F,Kroemer G,Boneca IG,Zitvogel L,Daillère R
17-7177-81 was used in Flow cytometry/Cell sorting to surmise that immunological, metabolic, epithelial, and microbial modes of action of the live E. hirae cooperate to circumvent primary resistance to therapy.
Thu Jul 01 00:00:00 EDT 2021
A role for TASK2 channels in the human immunological synapse.
European journal of immunology
Fernández-Orth J,Rolfes L,Gola L,Bittner S,Andronic J,Sukhorukov VL,Sisario D,Landgraf P,Dieterich DC,Cerina M,Smalla KH,Kähne T,Budde T,Kovac S,Ruck T,Sauer M,Meuth SG
17-7177 was used in Flow cytometry/Cell sorting to suggest that, together with Kv 1.3 and KCa3.1 channels, TASK2 channels contribute to the proper functioning of the immunological synapse, and represent an interesting treatment target for T cell-mediated autoimmune disorders.
Mon Feb 01 00:00:00 EST 2021
Transfer of Th17 from Adult Spontaneous Hypertensive Rats Accelerates Development of Hypertension in Juvenile Spontaneous Hypertensive Rats.
BioMed research international
Kim JY,Lee E,Koo S,Kim CW,Kim I
17-7177 was used in Flow cytometry/Cell sorting to test the hypothesis that the transfer of Th17 cells from adult spontaneous hypertensive rats (SHR) accelerates the development of hypertension in juvenile SHR.
Tue May 25 00:00:00 EDT 2021
Features of T-cell subset composition in a D-galactose-induced senescence mouse model.
Experimental animals
Kawata K,Suzuki T,Ozawa K,Sekiguchi M
17-7177-81 was used in Flow Cytometry to examine the immunological characteristics, especially CD4+ T-cell subset composition, of D-galactose-induced aging model mice to evaluate the model's utility in immunosenescence studies.
Fri Aug 06 00:00:00 EDT 2021
Qing-Luo-Yin Alleviated Experimental Arthritis in Rats by Disrupting Immune Feedback Between Inflammatory T Cells and Monocytes: Key Evidences from Its Effects on Immune Cell Phenotypes.
Journal of inflammation research
Wang DD,Wu XY,Dong JY,Cheng XP,Gu SF,Olatunji OJ,Li Y,Zuo J
17-7177-81 was used in Flow Cytometry to investigate the changes in CD4+ T cells and monocytes in Qing-Luo-Yin-treated rheumatoid arthritis animal models.
Fri Apr 29 00:00:00 EDT 2022
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
17-7177 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.
The Journal of experimental medicine
Devos M,Tanghe G,Gilbert B,Dierick E,Verheirstraeten M,Nemegeer J,de Reuver R,Lefebvre S,De Munck J,Rehwinkel J,Vandenabeele P,Declercq W,Maelfait J
17-7177 was used in Flow cytometry/Cell sorting to show that sensing of endogenous nucleic acids by ZBP1 is critical in driving skin pathology characterised by antiviral and IL-17 immune responses.
Mon Jul 06 00:00:00 EDT 2020
Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats.
Disease models & mechanisms
Lee E,Kim N,Kang J,Yoon S,Lee HA,Jung H,Kim SH,Kim I
17-7177 was used in Flow cytometry/Cell sorting to demonstrate that activation of pathogenic Th17 lymphocytes induces hypertension after high-fructose intake in SS rats but not SR rats.
Wed May 27 00:00:00 EDT 2020
IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy.
Journal of cellular and molecular medicine
Cong LH,Li T,Wang H,Wu YN,Wang SP,Zhao YY,Zhang GQ,Duan J
17-7177 was used in Flow cytometry/Cell sorting to suggest that PM2.5 could inhibit autophagy of bronchial epithelial cells and promote pulmonary inflammation and fibrosis by inducing the secretion of IL-17A in γδT and Th17 cells and regulating the PI3K/Akt/mTOR signalling pathway.
Sat Aug 01 00:00:00 EDT 2020
A novel inhibitory role of microRNA-224 in particulate matter 2.5-induced asthmatic mice by inhibiting TLR2.
Journal of cellular and molecular medicine
Li P,Wang J,Guo F,Zheng B,Zhang X
17-7177-81 was used in Flow cytometry/Cell sorting to explore the effect of miR-224 on PM2.5-induced asthmatic mice.
Sun Mar 01 00:00:00 EST 2020
Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate.
Veterinary research
Sisteré-Oró M,Pedersen GK,Córdoba L,López-Serrano S,Christensen D,Darji A
17-7177 was used in Flow cytometry/Cell sorting to define the most efficient combination of antigen / adjuvant to combat influence virus infections.
Mon Apr 20 00:00:00 EDT 2020
FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.
Cell death & disease
Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY
17-7177 was used in Flow cytometry/Cell sorting to investigate the effects of FUT1 on the ocular surface in steady-state conditions with age and under desiccating stress using a Fut1 knockout (KO) mouse model.
Fri Apr 24 00:00:00 EDT 2020
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
17-7177 was used in Flow cytometry/Cell sorting to suggest that age-dependent DED in C57BL/6 mice is related to inflammation of the LGs, the development of MG atrophy, and oxidative stress in both glands.
Thu Jun 11 00:00:00 EDT 2020
The frequency of follicular T helper cells differs in acute and chronic neuroinflammation.
Scientific reports
Baniahmad A,Birkner K,Görg J,Loos J,Zipp F,Wasser B,Bittner S
17-7177-81 was used in Flow Cytometry to investigate the distribution of follicular T helper cells during disease progression towards understanding their role in autoimmune neuroinflammation.
Tue Nov 24 00:00:00 EST 2020
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Cell reports
Ramstead AG,Wallace JA,Lee SH,Bauer KM,Tang WW,Ekiz HA,Lane TE,Cluntun AA,Bettini ML,Round JL,Rutter J,O'Connell RM
17-7177 was used in Flow cytometry/Cell sorting to demonstrate that pyruvate oxidation by T cell precursors is necessary for optimal αβ T cell development.
Tue Mar 03 00:00:00 EST 2020
Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.
JCI insight
Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY
17-7177 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.
Thu Jun 18 00:00:00 EDT 2020
Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells.
Cell reports
Yang YH,Istomine R,Alvarez F,Al-Aubodah TA,Shi XQ,Takano T,Thornton AM,Shevach EM,Zhang J,Piccirillo CA
17-7177-81 was used in Flow Cytometry to show that high salt (HS) drives thymic Treg cells to adopt a T helper type 17 (Th17)-like phenotype and enhances generation of Th17-like induced Treg cells in a SGK1-dependent manner, all the while maintaining suppressive function.
Tue Feb 04 00:00:00 EST 2020
M1 Macrophage Derived Exosomes Aggravate Experimental Autoimmune Neuritis via Modulating Th1 Response.
Frontiers in immunology
Du T,Yang CL,Ge MR,Liu Y,Zhang P,Li H,Li XL,Li T,Liu YD,Dou YC,Yang B,Duan RS
17-7177 was used in Flow cytometry/Cell sorting to determine the effects of macrophage derived exosomes on the development of EAN in Lewis rats.
Tue Apr 13 00:00:00 EDT 2021
Characterization of Rat ILCs Reveals ILC2 as the Dominant Intestinal Subset.
Frontiers in immunology
Abidi A,Laurent T,Bériou G,Bouchet-Delbos L,Fourgeux C,Louvet C,Triki-Marrakchi R,Poschmann J,Josien R,Martin J
17-7177 was used in Flow cytometry/Cell sorting to demonstrate that in spite of highly conserved phenotype and function between mice, rat and humans, the distribution of ILC subsets in the intestinal mucosa is dependent on the species likely in response to both genetic and environmental factors.
Thu Mar 18 00:00:00 EDT 2021
Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.
The Journal of clinical investigation
Kaushik DK,Bhattacharya A,Mirzaei R,Rawji KS,Ahn Y,Rho JM,Yong VW
17-7177-81 was used in Flow Cytometry to explore the metabolism of macrophages for transmigration from perivascular cuffs into the CNS parenchyma and identify α-cyano-4-hydroxy-cinnamic acid and diet as modulators of neuroinflammation of multiple sclerosis.
Tue May 21 00:00:00 EDT 2019
KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis.
Journal of neuroinflammation
Niu T,Cheng L,Wang H,Zhu S,Yang X,Liu K,Jin H,Xu X
17-7177 was used in Flow cytometry/Cell sorting to evaluate the preventive effect of KS23 in experimental autoimmune uveitis (EAU).
Sat Dec 28 00:00:00 EST 2019
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.
Nature communications
Luu M,Pautz S,Kohl V,Singh R,Romero R,Lucas S,Hofmann J,Raifer H,Vachharajani N,Carrascosa LC,Lamp B,Nist A,Stiewe T,Shaul Y,Adhikary T,Zaiss MM,Lauth M,Steinhoff U,Visekruna A
17-7177-81 was used in Flow Cytometry to show that pentanoate, a physiologically abundant SCFA, is a potent regulator of immunometabolism.
Fri Feb 15 00:00:00 EST 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
17-7177 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 EDT 2019
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation.
Nature communications
Zhou J,Huang S,Wang Z,Huang J,Xu L,Tang X,Wan YY,Li QJ,Symonds ALJ,Long H,Zhu B
17-7177-81 was used in Flow Cytometry to report that suppressing EZH2 activity ameliorates experimental intestinal inflammation and delayed the onset of colitis-associated cancer.
Mon Jun 03 00:00:00 EDT 2019
Bryostatin-1 alleviates experimental multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM
17-7177 was used in Flow cytometry/Cell sorting to study the effects of bryostatin-1 on the pathology of murine experimental autoimmune encephalomyelitis, with potential applications in progressive forms of multiple sclerosis.
Tue Feb 27 00:00:00 EST 2018
Heterologous Prime-Boost Combinations Highlight the Crucial Role of Adjuvant in Priming the Immune System.
Frontiers in immunology
Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D
17-7177 was used in Flow cytometry/Cell sorting to investigate the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial vaccine antigen on C57BL/6 mice.
Mon Apr 08 00:00:00 EDT 2019
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
17-7177-81 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
CCR7 on CD4+ T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Belikan P,Bühler U,Wolf C,Pramanik GK,Gollan R,Zipp F,Siffrin V
17-7177 was used in Flow cytometry/Cell sorting to indicate a crucial role of CCR7 in neuroinflammation during the priming of autoimmune CD4+ T cells but not in the CNS.
Sun Apr 15 00:00:00 EDT 2018
Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice.
Infection and immunity
Gomes RS,Silva MVT,Dos Santos JC,van Linge C,Reis JM,Teixeira MM,Pinto SA,Dorta ML,Bai X,Chan ED,Dinarello CA,Oliveira MAP,Joosten LAB,Ribeiro-Dias F
17-7177 was used in Flow cytometry/Cell sorting to study the role of interleukin-32γ in potentiating the Th1/Th17 immune response during experimental visceral leishmaniasis.
Tue May 01 00:00:00 EDT 2018
Epigallocatechin gallate improves airway inflammation through TGF‑β1 signaling pathway in asthmatic mice.
Molecular medicine reports
Shan L,Kang X,Liu F,Cai X,Han X,Shang Y
17-7177-81 was used in Flow Cytometry to study the effect of epigallocatachin gallate on airway inflammation in bronchial asthma.
Wed Aug 01 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
17-7177 was used in Flow cytometry/Cell sorting to demonstrate that Chitinase-3-like-1 is a regulator of Th1 and CTL, which could be a potential anti-tumor immunity target.
Mon Feb 05 00:00:00 EST 2018
mTOR complexes differentially orchestrates eosinophil development in allergy.
Scientific reports
Zhu C,Xia L,Li F,Zhou L,Weng Q,Li Z,Wu Y,Mao Y,Zhang C,Wu Y,Li M,Ying S,Chen Z,Shen H,Li W
17-7177 was used in Flow cytometry/Cell sorting to investigate the role of mTOR in eosinophil differentiation in the context of asthmatic pathogenesis.
Wed May 02 00:00:00 EDT 2018
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Immunity
Hayatsu N,Miyao T,Tachibana M,Murakami R,Kimura A,Kato T,Kawakami E,Endo TA,Setoguchi R,Watarai H,Nishikawa T,Yasuda T,Yoshida H,Hori S
17-7177-81 was used in Flow Cytometry to identify BATF as a regulator of tissue regulatory T (Treg) cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg physiology and the immunopathologies.
Tue Aug 15 00:00:00 EDT 2017
Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.
Circulation research
Yan X,Zhang H,Fan Q,Hu J,Tao R,Chen Q,Iwakura Y,Shen W,Lu L,Zhang Q,Zhang R
17-7177 was used in Flow cytometry/Cell sorting to determine whether Dectin-2 signalling is involved in the healing process and cardiac remodelling after myocardial infarction and to elucidate the underlying molecular mechanisms.
Fri Mar 31 00:00:00 EDT 2017
Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.
The Journal of allergy and clinical immunology
Joetham A,Schedel M,O'Connor BP,Kim S,Takeda K,Abbott J,Gelfand EW
17-7177 was used in Flow cytometry/Cell sorting to study the differences between the pathways leading to enhancement of lung allergic responses by both transferred naturally occurring regulatory T and inducible regulatory T cells.
Sat Apr 01 00:00:00 EDT 2017
Upregulation of Intestinal Barrier Function in Mice with DSS-Induced Colitis by a Defined Bacterial Consortium Is Associated with Expansion of IL-17A Producing Gamma Delta T Cells.
Frontiers in immunology
Li M,Wang B,Sun X,Tang Y,Wei X,Ge B,Tang Y,Deng Y,He C,Yuan J,Li X
17-7177 was used in Flow cytometry/Cell sorting to investigate bacterial consortium transplantation as a treatment for IBD, showing an upregulation of intestinal barrier function associated with expansion of IL-17A producing gamma delta T cells.
Wed Nov 20 00:00:00 EST 2019
Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes.
Frontiers in immunology
Van Dyke MCC,Chaturvedi AK,Hardison SE,Leopold Wager CM,Castro-Lopez N,Hole CR,Wozniak KL,Wormley FL
17-7177 was used in Flow cytometry/Cell sorting to provide "proof-of-concept" for the development of a cryptococcal vaccine that provides cross-protection against multiple disparate serotypes of Cryptococcus.
Wed Nov 20 00:00:00 EST 2019
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
17-7177 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 EDT 2017
Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Yi P,Tang H,Soong L,Cong Y,Zhang K,Sun J
17-7177 was used in Flow cytometry/Cell sorting to determine the role of retinoic acid in IL-22 production during hepatitis infection.
Mon May 01 00:00:00 EDT 2017
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Franchi L,Monteleone I,Hao LY,Spahr MA,Zhao W,Liu X,Demock K,Kulkarni A,Lesch CA,Sanchez B,Carter L,Marafini I,Hu X,Mashadova O,Yuan M,Asara JM,Singh H,Lyssiotis CA,Monteleone G,Opipari AW,Glick GD
17-7177 was used in Flow cytometry/Cell sorting to highlight the importance of analysing metabolism in effector lymphocytes within in vivo inflammatory contexts.
Sat Apr 01 00:00:00 EDT 2017
Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis.
International journal of molecular sciences
Takemiya T,Takeuchi C,Kawakami M
17-7177-81 was used in Immunohistochemistry to identify that mPGES-1 stimulates an interaction between CD4+ T cells by upregulating IL-1β autocrine function in activated CD4+ T cells.
Tue Dec 19 00:00:00 EST 2017
Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses.
Scientific reports
Hu X,Li X,Hu C,Qin L,He R,Luo L,Tang W,Feng J
17-7177 was used in Flow cytometry/Cell sorting to indicate that respiratory syncytial virus infection can increase C5a and C5aR expression in the pathogenesis of infected, asthmatic mice.
Thu Nov 09 00:00:00 EST 2017
Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance.
Cell
Xiong H,Keith JW,Samilo DW,Carter RA,Leiner IM,Pamer EG
17-7177 was used in Flow cytometry/Cell sorting to demonstrate that inflammatory monocytes are recruited to the lungs of K. pneumoniae-infected mice, produce TNF, which increases IL-17-producing lymphoid cell numbers.
Thu Apr 21 00:00:00 EDT 2016
Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome.
Blood
Bocchini CE,Nahmod K,Katsonis P,Kim S,Kasembeli MM,Freeman A,Lichtarge O,Makedonas G,Tweardy DJ
17-7177 was used in Flow cytometry/Cell sorting to investigate whether autosomal dominant hyper-IgE syndrome mutations decrease STAT3 protein stability and if mutant STAT3 activity can be improved by agents that increase chaperone protein activity.
Thu Dec 29 00:00:00 EST 2016
Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.
Mucosal immunology
Yang BH,Hagemann S,Mamareli P,Lauer U,Hoffmann U,Beckstette M,Föhse L,Prinz I,Pezoldt J,Suerbaum S,Sparwasser T,Hamann A,Floess S,Huehn J,Lochner M
17-7177 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3(+) T cells expressing retinoic acid-related orphan receptor-γt, represent a stable regulatory T cell lineage with a highly suppressive phenotype in vivo.
Tue Mar 01 00:00:00 EST 2016
Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance.
European journal of immunology
Tibbitt C,Falconer J,Stoop J,van Eden W,Robinson JH,Hilkens CM
17-7177 was used in Flow cytometry/Cell sorting to investigate how citrullination of an immunedominant T-cell epitope affects Th17 development.
Fri Jul 01 00:00:00 EDT 2016
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sood S,Brownlie RJ,Garcia C,Cowan G,Salmond RJ,Sakaguchi S,Zamoyska R
17-7177 was used in Flow cytometry/Cell sorting to show that small perturbations in TCR signal transduction pathways can have profound consequences on T cell differentiation and the development of autoimmune disease.
Fri Jul 15 00:00:00 EDT 2016
Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage.
PloS one
Vicetti Miguel RD,Quispe Calla NE,Pavelko SD,Cherpes TL
17-7177 was used in Flow cytometry/Cell sorting to determine if intravaginal infection with occulogenital Chlamydia trachomatis is a possible mouse model for Chlamydia infection in humans.
Fri Aug 04 00:00:00 EDT 2017
IL-22 dampens the T cell response in experimental malaria.
Scientific reports
Sellau J,Alvarado CF,Hoenow S,Mackroth MS,Kleinschmidt D,Huber S,Jacobs T
17-7177 was used in Flow cytometry/Cell sorting to study IL-22 levels during plasmodial infection in mice and the effect on an adaptive immune response.
Fri Jun 17 00:00:00 EDT 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
17-7177 was used in Flow cytometry/Cell sorting to investigate the role of IL-9 in allergic asthma and autoimmunity, showing that Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Thu Mar 03 00:00:00 EST 2016
MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.
eLife
Ogawa Y,Morikawa S,Okano H,Mabuchi Y,Suzuki S,Yaguchi T,Sato Y,Mukai S,Yaguchi S,Inaba T,Okamoto S,Kawakami Y,Tsubota K,Matsuzaki Y,Shimmura S
17-7177 was used in Flow cytometry/Cell sorting to investigate the fibrosis in a scleroderma mouse model which is triggered by antigen mismatched bone marrow stromal/stem cells.
Tue Jan 26 00:00:00 EST 2016
Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway.
Scientific reports
Song ZH,Li ZY,Li DD,Fang WN,Liu HY,Yang DD,Meng CY,Yang Y,Peng JP
17-7177 was used in Flow cytometry/Cell sorting to identify a new mechanism by which seminal plasma could influence inflammation in the uterus through the γδ T/IL-17 pathway.
Mon Apr 25 00:00:00 EDT 2016
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Nature
Najm FJ,Madhavan M,Zaremba A,Shick E,Karl RT,Factor DC,Miller TE,Nevin ZS,Kantor C,Sargent A,Quick KL,Schlatzer DM,Tang H,Papoian R,Brimacombe KR,Shen M,Boxer MB,Jadhav A,Robinson AP,Podojil JR,Miller SD,Miller RH,Tesar PJ
17-7177 was used in Flow cytometry/Cell sorting to study the drug-based modulation of endogenous stem cells which promotes functional remyelination in vivo.
Thu Jun 11 00:00:00 EDT 2015
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Nature immunology
Basu R,Whitley SK,Bhaumik S,Zindl CL,Schoeb TR,Benveniste EN,Pear WS,Hatton RD,Weaver CT
17-7177 was used in Flow cytometry/Cell sorting to assess the ability of IL-1 to override retinoic acid-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.
Sun Mar 01 00:00:00 EST 2015
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
The Journal of experimental medicine
Pallangyo CK,Ziegler PK,Greten FR
17-7177 was used in Flow cytometry/Cell sorting to highlight an unexpected tumor suppressive function of IKKβ/NF-κB in CAFs linked to HGF release.
Mon Dec 14 00:00:00 EST 2015
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.
Proceedings of the National Academy of Sciences of the United States of America
Hashimoto-Kataoka T,Hosen N,Sonobe T,Arita Y,Yasui T,Masaki T,Minami M,Inagaki T,Miyagawa S,Sawa Y,Murakami M,Kumanogoh A,Yamauchi-Takihara K,Okumura M,Kishimoto T,Komuro I,Shirai M,Sakata Y,Nakaoka Y
17-7177 was used in Flow cytometry/Cell sorting to suggest that IL-21 promotes PAH in association with M2 macrophage polarisation, downstream of IL-6-signalling.
Tue May 19 00:00:00 EDT 2015
Control of murine cytomegalovirus infection by γδ T cells.
PLoS pathogens
Sell S,Dietz M,Schneider A,Holtappels R,Mach M,Winkler TH
17-7177 was used in Immunocytochemistry to show that γδ T cells can provide an effective control mechanism of acute cytomegalovirus infections.
Sun Feb 01 00:00:00 EST 2015
Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.
Journal of immunology (Baltimore, Md. : 1950)
Siggs OM,Miosge LA,Daley SR,Asquith K,Foster PS,Liston A,Goodnow CC
17-7177 was used in Flow cytometry/Cell sorting to investigate whether outcomes of null mutations of SLP-76 are due to biochemical uncoupling of tolerogenic signaling, showing that reduction of SLP-76 unbalances immunity and immune regulation.
Sun Mar 15 00:00:00 EDT 2015
Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease.
Journal of immunology (Baltimore, Md. : 1950)
Gao Y,Min K,Zhang Y,Su J,Greenwood M,Gronert K
17-7177 was used in Flow cytometry/Cell sorting to investigate the cause of sex-specific prevalence of immune-driven dry eye disease.
Thu Oct 01 00:00:00 EDT 2015
IκBNS regulates murine Th17 differentiation during gut inflammation and infection.
Journal of immunology (Baltimore, Md. : 1950)
Annemann M,Wang Z,Plaza-Sirvent C,Glauben R,Schuster M,Ewald Sander F,Mamareli P,Kühl AA,Siegmund B,Lochner M,Schmitz I
17-7177 was used in Flow cytometry/Cell sorting to study the role of nuclear IκBNS in murine Th17 cell generation upon inflammation and infection.
Sun Mar 15 00:00:00 EDT 2015
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
BioMed research international
Tejón G,Manríquez V,De Calisto J,Flores-Santibáñez F,Hidalgo Y,Crisóstomo N,Fernández D,Sauma D,Mora JR,Bono MR,Rosemblatt M
17-7177 was used in Flow cytometry/Cell sorting to study the contribution of different factors to the reprogramming of iTregs into IL-17-producing cells, showing that vitamin A impairs reprogramming during intestinal inflammation.
Fri Sep 02 00:00:00 EDT 2016
Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice.
PloS one
Schutt SD,Fu J,Nguyen H,Bastian D,Heinrichs J,Wu Y,Liu C,McDonald DG,Pidala J,Yu XZ
17-7177 was used in Flow cytometry/Cell sorting to show that Ibrutinib is an effective prophylaxis against mouse models of cGVHD with minimal toxicity.
Fri Jun 03 00:00:00 EDT 2016
Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic.
Nature communications
Way SW,Podojil JR,Clayton BL,Zaremba A,Collins TL,Kunjamma RB,Robinson AP,Brugarolas P,Miller RH,Miller SD,Popko B
17-7177 was used in Flow cytometry/Cell sorting to provide support for a MS therapy that enhances the integrated stress response to protect oligodendrocytes against the inflammatory CNS environment.
Fri Mar 13 00:00:00 EDT 2015
HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats.
PloS one
Marroquin Belaunzaran O,Kleber S,Schauer S,Hausmann M,Nicholls F,Van den Broek M,Payeli S,Ciurea A,Milling S,Stenner F,Shaw J,Kollnberger S,Bowness P,Petrausch U,Renner C
17-7177 was used in Flow cytometry/Cell sorting to characterise a novel B272-specific monoclonal antibody to study its therapeutic use in HLA-B27 associated disorders.
Fri Apr 15 00:00:00 EDT 2016
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
17-7177 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
17-7177 was used in Flow cytometry/Cell sorting to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.
Tue Apr 01 00:00:00 EDT 2014
Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Jiao J,Dragomir AC,Kocabayoglu P,Rahman AH,Chow A,Hashimoto D,Leboeuf M,Kraus T,Moran T,Carrasco-Avino G,Friedman SL,Merad M,Aloman C
17-7177 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells in neutrophil homeostasis, showing a central role in regulation of bone marrow release and survival of neutrophils.
Tue Apr 01 00:00:00 EDT 2014
Progression of relapsing-remitting demyelinating disease does not require increased TCR affinity or epitope spread.
Journal of immunology (Baltimore, Md. : 1950)
Kersh AE,Edwards LJ,Evavold BD
17-7177 was used in Immunofluorescence to study how a high frequency of T cells specific for a single myelin Ag governs the transition from acute symptoms through remission, relapse, and chronic disease states.
Sat Nov 01 00:00:00 EDT 2014
T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity.
eLife
Burger ML,Leung KK,Bennett MJ,Winoto A
17-7177 was used in Flow cytometry/Cell sorting to show that T cell-specific expression of a Bcl2 BH3 mutant transgene results in enhanced rescue of thymocytes from negative selection.
Tue Sep 02 00:00:00 EDT 2014
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Nature immunology
Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A
17-7177 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.
Sun Sep 01 00:00:00 EDT 2013
Enhanced inducible costimulator ligand (ICOS-L) expression on dendritic cells in interleukin-10 deficiency and its impact on T-cell subsets in respiratory tract infection.
Molecular medicine (Cambridge, Mass.)
Gao X,Zhao L,Wang S,Yang J,Yang X
17-7177 was used in Flow cytometry/Cell sorting to test the relationship between Interleukin-10 production and Enhanced Inducible Costimulator Ligand (ICOS-L) expression by dendritic cells.
Fri Nov 08 00:00:00 EST 2013
Enhanced inducible costimulator ligand (ICOS-L) expression on dendritic cells in interleukin-10 deficiency and its impact on T-cell subsets in respiratory tract infection.
Molecular medicine (Cambridge, Mass.)
Gao X,Zhao L,Wang S,Yang J,Yang X
17-7177 was used in Flow cytometry/Cell sorting to test the relationship between Interleukin-10 production and Enhanced Inducible Costimulator Ligand (ICOS-L) expression by dendritic cells.
Fri Nov 08 00:00:00 EST 2013
IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells.
Journal of immunology (Baltimore, Md. : 1950)
Ding Y,Li J,Wu Q,Yang P,Luo B,Xie S,Druey KM,Zajac AJ,Hsu HC,Mountz JD
17-7177 was used in Flow cytometry/Cell sorting to investigate the role of germinal centres in autoimmunity, showing that IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells.
Thu Aug 15 00:00:00 EDT 2013
Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Yu Y,Cho HI,Wang D,Kaosaard K,Anasetti C,Celis E,Yu XZ
17-7177 was used in Flow cytometry/Cell sorting to demonstrate that both Tc1 and Tc17 cells can mediate effective antitumor immunity through distinct effector mechanisms.
Fri Feb 15 00:00:00 EST 2013
Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Dunham RM,Thapa M,Velazquez VM,Elrod EJ,Denning TL,Pulendran B,Grakoui A
17-7177 was used in Immunocytochemistry to demonstrate a potential Treg enrichment role for hepatic stellate cells, supporting the tolerogenic nature of the liver.
Fri Mar 01 00:00:00 EST 2013
Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.
PLoS computational biology
Carbo A,Hontecillas R,Kronsteiner B,Viladomiu M,Pedragosa M,Lu P,Philipson CW,Hoops S,Marathe M,Eubank S,Bisset K,Wendelsdorf K,Jarrah A,Mei Y,Bassaganya-Riera J
17-7177 was used in Flow cytometry/Cell sorting to investigate the mechanisms controlling differentiation and plasticity of CD4+ T cells in the gut of mice.
Mon Apr 01 00:00:00 EDT 2013
n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells.
The Journal of nutrition
Monk JM,Hou TY,Turk HF,McMurray DN,Chapkin RS
17-7177 was used in Flow cytometry/Cell sorting to discern the effect of n3 PUFAs on the CD4+ T-cells of mice.
Sun Sep 01 00:00:00 EDT 2013
Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.
The Journal of biological chemistry
Wong LY,Hatfield JK,Brown MA
17-7177 was used in Flow cytometry/Cell sorting to investigate the factors that influence the development of Th17 cells, showing that lineage gene expression is set by Ikaros.
Fri Dec 06 00:00:00 EST 2013
Analysis of the dynamics of infiltrating CD4(+) T cell subsets in the heart during experimental Trypanosoma cruzi infection.
PloS one
Sanoja C,Carbajosa S,Fresno M,Gironès N
17-7177 was used in Flow cytometry/Cell sorting to compare CD4+ T cell subsets after infection with the T. cruzi Y strain in susceptible and nonsusceptible mice.
Thu Jan 16 00:00:00 EST 2014
Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.
Nature biotechnology
Getts DR,Martin AJ,McCarthy DP,Terry RL,Hunter ZN,Yap WT,Getts MT,Pleiss M,Luo X,King NJ,Shea LD,Miller SD
17-7177 was used in Flow cytometry/Cell sorting to highlight the potential for using microparticles to target natural apoptotic clearance pathways to inactivate pathogenic T cells in autoimmunity.
Sat Dec 01 00:00:00 EST 2012
Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.
Immunity
Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK
17-7177 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.
Fri Apr 20 00:00:00 EDT 2012
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
The Journal of experimental medicine
Cherrier M,Sawa S,Eberl G
17-7177 was used in Flow cytometry/Cell sorting to investigate the development of lymphoid tissue inducer (LTi) cells from common lymphoid progenitors (CLPs) in the fetal liver, showing that sequential changes in expression of Notch, Id2, and RORγt orchestrate the development of LTi cells.
Mon Apr 09 00:00:00 EDT 2012
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Journal of autoimmunity
Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A
17-7177 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.
Wed Feb 01 00:00:00 EST 2012
CD4 T cells play important roles in maintaining IL-17-producing γδ T-cell subsets in naive animals.
Immunology and cell biology
Do JS,Visperas A,O'Brien RL,Min B
17-7177 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying the regulation of αβ and γδ T-cell homeostasis, showing that CD4 T cells play important roles in maintaining IL-17-producing subsets.
Sun Apr 01 00:00:00 EDT 2012
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
Journal of immunology (Baltimore, Md. : 1950)
Ribot JC,Debarros A,Mancio-Silva L,Pamplona A,Silva-Santos B
17-7177 was used in Flow cytometry/Cell sorting to show that CD28 signals are required for IL-2-mediated survival and proliferation of both CD27(+) and CD27(-) γδ T cell subsets.
Wed Aug 01 00:00:00 EDT 2012
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ
17-7177 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.
Tue May 01 00:00:00 EDT 2012
Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4(+) T-cell Differentiation.
Frontiers in immunology
Rohlman D,Pham D,Yu Z,Steppan LB,Kerkvliet NI
17-7177 was used in Flow cytometry/Cell sorting to characterise the influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin-activated aryl hydrocarbon receptor on gene expression during CD4+ T-cell differentiation.
Thu Aug 23 00:00:00 EDT 2012
Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.
Journal of the American Heart Association
Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M
17-7177 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.
Mon Oct 01 00:00:00 EDT 2012
Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice.
Blood
Yu Y,Wang D,Liu C,Kaosaard K,Semple K,Anasetti C,Yu XZ
17-7177 was used in Flow cytometry/Cell sorting to indicate that GVHD can be prevented by targeting Th1 and Th17 transcription factors without offsetting GVL activity.
Thu Nov 03 00:00:00 EDT 2011
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.
Blood
Tian L,Altin JA,Makaroff LE,Franckaert D,Cook MC,Goodnow CC,Dooley J,Liston A
17-7177 was used in Immunocytochemistry to demonstrate that Th2-driven diseases may be more responsive to regulatory T-cell manipulation.
Thu Aug 18 00:00:00 EDT 2011
Modulation of regulatory T cell-Th17 balance by plasmacytoid dendritic cells.
Journal of leukocyte biology
Gautreau L,Chabannes D,Heslan M,Josien R
17-7177 was used in Flow cytometry/Cell sorting to analyse the role of pDCs versus cDCs on regulatory T cell responses.
Thu Sep 01 00:00:00 EDT 2011
Modulation of regulatory T cell-Th17 balance by plasmacytoid dendritic cells.
Journal of leukocyte biology
Gautreau L,Chabannes D,Heslan M,Josien R
17-7177 was used in Flow cytometry/Cell sorting to analyse the role of pDCs versus cDCs on regulatory T cell responses.
Thu Sep 01 00:00:00 EDT 2011
Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.
International immunopharmacology
Cao H,Lan Q,Shi Q,Zhou X,Liu G,Liu J,Tang G,Qiu C,Qiu C,Xu J,Fan H,Liu Z
Sun May 01 00:00:00 EDT 2011
IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.
International immunology
Yabu M,Shime H,Hara H,Saito T,Matsumoto M,Seya T,Akazawa T,Inoue N
17-7177 was used in Flow cytometry/Cell sorting to show lactic acid functions as an inflammatory mediator that activates IL-23-dependent and -independent pathways to promote chronic inflammation in tumour microenvironments.
Sat Jan 01 00:00:00 EST 2011
Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.
BMC immunology
Assi K,Patterson S,Dedhar S,Owen D,Levings M,Salh B
Mon Aug 01 00:00:00 EDT 2011
T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.
Immunity
Park SG,Mathur R,Long M,Hosh N,Hao L,Hayden MS,Ghosh S
17-7177 was used in Flow cytometry/Cell sorting to explore the regulatory processes maintaining a tolerogenic attitude towards enteric commensal bacteria.
Wed Nov 24 00:00:00 EST 2010
Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis.
The American journal of pathology
Zhang Z,Zhong W,Hinrichs D,Wu X,Weinberg A,Hall M,Spencer D,Wegmann K,Rosenbaum JT
17-7177 was used in Flow cytometry/Cell sorting to show that activated Th17 cells express OX40, and the stimulation of this receptor significantly augments Th17 cytokine production.
Wed Dec 01 00:00:00 EST 2010
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B
17-7177 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.
Mon Feb 15 00:00:00 EST 2010
Critical role of regulatory T cells in Th17-mediated minor antigen-disparate rejection.
Journal of immunology (Baltimore, Md. : 1950)
Vokaer B,Van Rompaey N,Lemaître PH,Lhommé F,Kubjak C,Benghiat FS,Iwakura Y,Petein M,Field KA,Goldman M,Le Moine A,Charbonnier LM
17-7177 was used in Flow cytometry/Cell sorting to discover the ability of Tregs to promote the Th17/neutrophil-mediated pathway of rejection as a potential drawback of Treg-based cell therapy.
Wed Sep 15 00:00:00 EDT 2010
Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Cha HR,Chang SY,Chang JH,Kim JO,Yang JY,Kim CH,Kweon MN
17-7177 was used in Flow cytometry/Cell sorting to investigate the role of retinoic acid in Th17/regulatory T cell generation in vivo.
Tue Jun 15 00:00:00 EDT 2010
1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis.
PloS one
Chang JH,Cha HR,Lee DS,Seo KY,Kweon MN
17-7177 was used in Flow cytometry/Cell sorting to suggest that 1,25(OH)(2)D(3) can directly regulate T cell differentiation in an experimental murine model.
Thu Sep 23 00:00:00 EDT 2010
Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ellestad KK,Tsutsui S,Noorbakhsh F,Warren KG,Yong VW,Pittman QJ,Power C
Wed Jul 01 00:00:00 EDT 2009
SHIP regulates the reciprocal development of T regulatory and Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Locke NR,Patterson SJ,Hamilton MJ,Sly LM,Krystal G,Levings MK
17-7177 was used in an ELISA assay to investigate whether SHIP, a lipid phosphatase that regulates PI3K activity, also plays a role in the development and function of Tregs.
Wed Jul 15 00:00:00 EDT 2009
