Product References
FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.
Life science alliance
Kulkarni R,Kasani SK,Tsai CY,Tung SY,Yeh KH,Yu CA,Chang W
47-0112-82 was used in Flow cytometry/Cell sorting to highlight the importance of FAM21-TLR2/CLEC4E axis in a host immune response against the lethal C. albicans infection.
Sat Apr 01 00:00:00 EDT 2023
Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain.
Journal of neuroinflammation
Li Y,Khan N,Ritzel RM,Lei Z,Allen S,Faden AI,Wu J
47-0112-82 was used in Flow cytometry/Cell sorting to investigate the impact of biological sex and aging on extracellular vesicles and brain after spinal cord injury.
Thu Aug 31 00:00:00 EDT 2023
Establishment and Characterization of Free-Floating 3D Macrophage Programming Model in the Presence of Cancer Cell Spheroids.
International journal of molecular sciences
Korotkaja K,Jansons J,Spunde K,Rudevica Z,Zajakina A
47-0112-82 was used in Flow cytometry/Cell sorting to establish and characterized a new in vitro 3D model for macrophage programming in the presence of cancer cell spheroids.
Wed Jun 28 00:00:00 EDT 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
47-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Autophagy
Cai W,Hu M,Li C,Wu R,Lu D,Xie C,Zhang W,Li T,Shen S,Huang H,Qiu W,Liu Q,Lu Y,Lu Z
47-0112-82 was used in Flow Cytometry to demonstrate a distinct set of FOXP3+ macrophages with enhanced scavenging capability, which could be a target in immunomodulatory therapy against AIS.Abbreviations: ADGRE1/F4/80: adhesion G protein-coupled receptor E1; AIF1/Iba1: allograft inflammatory factor 1; AIS: acute ischemic stroke; ARG1: arginase 1; ATP: adenosine triphosphate; BECN1/Beclin1:.
Sat Apr 01 00:00:00 EDT 2023
Pexidartinib synergize PD-1 antibody through inhibiting treg infiltration by reducing TAM-derived CCL22 in lung adenocarcinoma.
Frontiers in pharmacology
Zhang W,Jiang X,Zou Y,Yuan L,Wang X
47-0112-82 was used in Flow Cytometry to show that the combination of pexidartinib and PD-1 antibody showed a synergy and significantly improved the anti-tumor efficacy, through pexidartinib increasing CD8T/Treg ratio by reducing TAM-derived CCL22.
Tue Mar 28 00:00:00 EDT 2023
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum.
PLoS neglected tropical diseases
Zhou L,Zhu Y,Mo L,Wang M,Lin J,Zhao Y,Feng Y,Xie A,Wei H,Qiu H,Huang J,Yang Q
47-0112-82 was used in Immunohistochemistry (Paraffin) to indicate that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.
Sat Oct 01 00:00:00 EDT 2022
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum.
PLoS neglected tropical diseases
Zhou L,Zhu Y,Mo L,Wang M,Lin J,Zhao Y,Feng Y,Xie A,Wei H,Qiu H,Huang J,Yang Q
47-0112-82 was used in Immunohistochemistry (Paraffin) to indicate that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.
Sat Oct 01 00:00:00 EDT 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
47-0112-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease.
Mucosal immunology
Morris CR,Habibovic A,Dustin CM,Schiffers C,Lin MC,Ather JL,Janssen-Heininger YMW,Poynter ME,Utermohlen O,Krönke M,van der Vliet A
47-0112-82 was used in Flow cytometry/Cell sorting to reveal a contribution of macrophage-intrinsic DUOX1 in macrophage recruitment upon chronic HDM challenge, as well as features of macrophage activation that impact on type 2 inflammation and remodeling.
Sun May 01 00:00:00 EDT 2022
Brain innate immune response via miRNA-TLR7 sensing in polymicrobial sepsis.
Brain, behavior, and immunity
Zou L,He J,Gu L,Shahror RA,Li Y,Cao T,Wang S,Zhu J,Huang H,Chen F,Fan X,Wu J,Chao W
47-0112-82 was used in Flow cytometry/Cell sorting to establish an important role of extracellular miRNA and TLR7 sensing in sepsis-induced brain inflammation.
Tue Feb 01 00:00:00 EST 2022
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential.
Developmental cell
Frederico B,Martins I,Chapela D,Gasparrini F,Chakravarty P,Ackels T,Piot C,Almeida B,Carvalho J,Ciccarelli A,Peddie CJ,Rogers N,Briscoe J,Guillemot F,Schaefer AT,Saúde L,Reis e Sousa C
47-0112-82 was used in flow cytometry to report that DNGR-1 lineage tracing in mice identifies an ependymal cell subset, wherein resides latent regenerative potential.
Mon Aug 22 00:00:00 EDT 2022
Repolarization of Tumor-Infiltrating Myeloid Cells for Augmentation of CAR T Cell Therapies.
Frontiers in immunology
Luo W,Napoleon JV,Zhang F,Lee YG,Wang B,Putt KS,Low PS
47-0112-82 was used in Flow cytometry/Cell sorting to show that co-administration of the FA-TLR7-1A with the CAR T cell therapy not only repolarizes TAMs and MDSCs from an M2-like anti-inflammatory to M1-like pro-inflammatory phenotype, but also enhances both CAR T cell and endogenous T cell accumulation in solid tumors while concurrently increasing their states of activation.
Mon May 02 00:00:00 EDT 2022
Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses.
eLife
Lundahl MLE,Mitermite M,Ryan DG,Case S,Williams NC,Yang M,Lynch RI,Lagan E,Lebre FM,Gorman AL,Stojkovic B,Bracken AP,Frezza C,Sheedy FJ,Scanlan EM,O'Neill LAJ,Gordon SV,Lavelle EC
47-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that activation with IL-4 and IL-13 counterintuitively induces protective innate memory against mycobacterial challenge.
Thu Sep 29 00:00:00 EDT 2022
Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis.
Cell host & microbe
Pandey SP,Bender MJ,McPherson AC,Phelps CM,Sanchez LM,Rana M,Hedden L,Sangani KA,Chen L,Shapira JH,Siller M,Goel C,Verdú EF,Jabri B,Chang A,Chandran UR,Mullett SJ,Wendell SG,Singhi AD,Tilstra JS,Pierre JF,Arteel GE,Hinterleitner R,Meisel M
47-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that I3A is required for L. reuteri-induced Tc1 cell differentiation in vitro and AIH-like pathology in vivo, both of which are restrained by Tet2 within CD8 T cells.
Wed Jul 13 00:00:00 EDT 2022
Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation.
Nature cell biology
Meacham CE,Jeffery EC,Burgess RJ,Sivakumar CD,Arora MA,Stanley AM,Colby EM,Crane GM,Zhao Z,Morrison SJ
47-0112-82 was used in Flow cytometry/Cell sorting to find that adiponectin receptors are non-cell-autonomously required in haematopoietic cells to promote HSC quiescence and self-renewal.
Sun May 01 00:00:00 EDT 2022
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.
Science immunology
Christian DA,Adams TA,Shallberg LA,Phan AT,Smith TE,Abraha M,Perry J,Ruthel G,Clark JT,Pritchard GH,Aronson LR,Gossa S,McGavern DB,Kedl RM,Hunter CA
47-0112-82 was used in Flow Cytometry to investigate how conventional type 1 dendritic cells (cDC1s) in the peritoneal cavity's omentum coordinate innate responses to microbial challenge and provide secondary signals required for CD8+ T cell expansion and memory formation, particularly after intraperitoneal immunization with Toxoplasma gondii.
Fri Sep 30 00:00:00 EDT 2022
STAT1 Contributes to Microglial/Macrophage Inflammation and Neurological Dysfunction in a Mouse Model of Traumatic Brain Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao Y,Ma C,Chen C,Li S,Wang Y,Yang T,Stetler RA,Bennett MVL,Dixon CE,Chen J,Shi Y
47-0112-82 was used in Flow cytometry/Cell sorting to show excellent efficacy of a selective STAT1 inhibitor fludarabine against TBI-induced functional deficits and brain injury using a mouse model, presenting STAT1 as a promising therapeutic target for TBI.
Wed Sep 28 00:00:00 EDT 2022
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia.
Nature genetics
Gu Z,Liu Y,Zhang Y,Cao H,Lyu J,Wang X,Wylie A,Newkirk SJ,Jones AE,Lee M,Botten GA,Deng M,Dickerson KE,Zhang CC,An W,Abrams JM,Xu J
47-0112-82 was used in Flow Cytometry to describe a tumor-suppressive role for L1 retrotransposons in myeloid leukemia.
Sat May 01 00:00:00 EDT 2021
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.
Molecular psychiatry
Ledo JH,Liebmann T,Zhang R,Chang JC,Azevedo EP,Wong E,Silva HM,Troyanskaya OG,Bustos V,Greengard P
47-0112 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism by which PS1 modulates microglial function and contributes to Alzheimer's -associated phenotypes.
Fri Oct 01 00:00:00 EDT 2021
Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates.
eLife
Issah Y,Naik A,Tang SY,Forrest K,Brooks TG,Lahens N,Theken KN,Mermigos M,Sehgal A,Worthen GS,FitzGerald GA,Sengupta S
47-0112-82 was used in Flow Cytometry to show that neonatal hyperoxia abolishes the clock-mediated time of day protection from influenza A virus in mice, independent of viral burden through host tolerance pathways.
Tue Mar 02 00:00:00 EST 2021
Combined OX40 Agonist and PD-1 Inhibitor Immunotherapy Improves the Efficacy of Vascular Targeted Photodynamic Therapy in a Urothelial Tumor Model.
Molecules (Basel, Switzerland)
Alvim RG,Georgala P,Nogueira L,Somma AJ,Nagar K,Thomas J,Alvim L,Riegel A,Hughes C,Chen J,Reis AB,Lebdai S,Scherz A,Zanganeh S,Gardner R,Kim K,Coleman JA
47-0112-82 was used in Flow Cytometry to study the efficacy of the vascular targeted photodynamic therapy in combination with concurrent PD-1 inhibitor/OX40 agonist immunotherapy in a urothelial tumor-bearing model.
Sat Jun 19 00:00:00 EDT 2021
Isolation of stromal vascular fraction cell suspensions from mouse and human adipose tissues for downstream applications.
STAR protocols
Hearnden R,Sandhar B,Vyas V,Longhi MP
47-0112-82 was used in flow cytometry to investigate isolation of stroll vascular fraction cells.
Fri Jun 18 00:00:00 EDT 2021
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers.
Oncoimmunology
Tata A,Dodard G,Fugère C,Leget C,Ors M,Rossi B,Vivier E,Brossay L
47-0112-82 was used in Flow Cytometry to demonstrate if killer cell lectin-like receptor G1 is a novel checkpoint inhibitor target that affects NK and T cell anti-tumor immunity.
Tue Jun 15 00:00:00 EDT 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
47-0112-82 was used in Flow Cytometry to find that TNF-α-mediated alterations in CML BM stromal niches enhance support of LSC maintenance and growth via CXCL1-CXCR2 signaling and that CXCR2 inhibition effectively depletes CML LSCs.
Tue Jul 13 00:00:00 EDT 2021
Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment.
Cell
Lam KC,Araya RE,Huang A,Chen Q,Di Modica M,Rodrigues RR,Lopès A,Johnson SB,Schwarz B,Bohrnsen E,Cogdill AP,Bosio CM,Wargo JA,Lee MP,Goldszmid RS
47-0112-82 was used in Flow cytometry/Cell sorting to uncover a mechanistic link between the microbiota and the innate TME that can be harnessed to improve cancer therapies.
Thu Oct 14 00:00:00 EDT 2021
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
47-0112 was used in Flow cytometry/Cell sorting to investigate the function of brain-resident CD4 T cells.
Thu Aug 06 00:00:00 EDT 2020
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.
Cell
Wu L,Hollinshead KER,Hao Y,Au C,Kroehling L,Ng C,Lin WY,Li D,Silva HM,Shin J,Lafaille JJ,Possemato R,Pacold ME,Papagiannakopoulos T,Kimmelman AC,Satija R,Littman DR
47-0112-82 was used in Flow Cytometry to suggest that inhibiting glycolysis by targeting Gpi1 could be an effective therapeutic strategy with minimum toxicity for Th17-mediated autoimmune diseases, and, more generally, that metabolic redundancies can be exploited for selective targeting of disease processes.
Thu Aug 06 00:00:00 EDT 2020
Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss.
Cell
Matheis F,Muller PA,Graves CL,Gabanyi I,Kerner ZJ,Costa-Borges D,Ahrends T,Rosenstiel P,Mucida D
47-0112-82 was used in Flow Cytometry to identify a mechanism of enteric-associated neuronal death post-infection and point to a role for tissue-resident muscularis macrophages in limiting neuronal damage.
Thu Jan 09 00:00:00 EST 2020
Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.
Nano-micro letters
Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y
47-0112-82 was used in Flow Cytometry to demonstrate that biomaterials developed to have specific regulatory capacities for immune cells can be used to control the early inflammatory responses of implanted materials and induce osteogenesis.
Sat Nov 21 00:00:00 EST 2020
Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice.
Brain, behavior, and immunity
Hahn J,Günter M,Schuhmacher J,Bieber K,Pöschel S,Schütz M,Engelhardt B,Oster H,Sina C,Lange T,Autenrieth SE
47-0112-82 was used in Flow Cytometry to elucidate whether sleep affects the numbers and functions of innate immune cells and their defense against systemic bacterial infection.
Wed Jul 01 00:00:00 EDT 2020
Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.
Developmental cell
Dege C,Fegan KH,Creamer JP,Berrien-Elliott MM,Luff SA,Kim D,Wagner JA,Kingsley PD,McGrath KE,Fehniger TA,Palis J,Sturgeon CM
47-0112 was used in Flow cytometry/Cell sorting to identify an extra-embryonic origin of potently cytotoxic NK cells, suggesting that ontogenic origin is a relevant factor in designing hPSC-derived adoptive immunotherapies.
Mon Apr 20 00:00:00 EDT 2020
Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation.
PLoS biology
Xu J,Yu T,Pietronigro EC,Yuan J,Arioli J,Pei Y,Luo X,Ye J,Constantin G,Mao C,Xiao Y
47-0112 was used in Flow cytometry/Cell sorting to establish Peli1 as a critical regulator of microglial phagocytosis by promoting CCAAT/enhancer-binding protein β (C/EBPβ) degradation.
Thu Oct 01 00:00:00 EDT 2020
Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis.
European journal of immunology
Dietschmann A,Schruefer S,Krappmann S,Voehringer D
47-0112-82 was used in Flow Cytometry to use a mouse model of ABPA to investigate the role of eosinophils and T cell-derived IL-4/IL-13 for induction of allergic lung inflammation.
Wed Jul 01 00:00:00 EDT 2020
Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke.
Experimental neurology
Srivastava P,Cronin CG,Scranton VL,Jacobson KA,Liang BT,Verma R
47-0112-82 was used in Flow Cytometry to suggest that acute P2X4R inhibition protects against ischemic injury both at acute and chronic time-points after stroke.
Wed Jul 01 00:00:00 EDT 2020
IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury.
Journal of immunology (Baltimore, Md. : 1950)
Miao W,Zhao Y,Huang Y,Chen D,Luo C,Su W,Gao Y
47-0112 was used in Flow cytometry/Cell sorting to demonstrate that IL-13 treatment improved neurologic outcomes after Traumatic Brain Injury through adjusting microglia/macrophage phenotypes and inhibiting inflammatory responses.
Sun Mar 15 00:00:00 EDT 2020
Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model.
American journal of physiology. Gastrointestinal and liver physiology
Okamura T,Hamaguchi M,Bamba R,Nakajima H,Yoshimura Y,Kimura T,Nishida K,Hashimoto Y,Fukuda T,Senmaru T,Fukui M
47-0112-82 was used in Flow cytometry/Cell sorting to suggest that a combination of estrogen and testosterone may be clinically relevant for the treatment of NAFLD in patients with male menopause.
Mon Jun 01 00:00:00 EDT 2020
Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury.
eLife
Lissner MM,Cumnock K,Davis NM,Vilches-Moure JG,Basak P,Navarrete DJ,Allen JA,Schneider D
47-0112 was used in Flow cytometry/Cell sorting to detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria.
Tue Oct 06 00:00:00 EDT 2020
GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.
Cells
Wang L,Li Y,Wang X,Wang P,Essandoh K,Cui S,Huang W,Mu X,Liu Z,Wang Y,Peng T,Fan GC
47-0112-82 was used in Flow Cytometry to show that serum GDF3 levels in septic patients are elevated and strongly correlate with severity of sepsis and 28-day mortality.
Fri Jan 03 00:00:00 EST 2020
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Scientific reports
Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A
47-0112 was used in Flow cytometry/Cell sorting to demonstrate that Ly6cLo non-classical monocytes promote resolution of RRV-mediated perinatal liver infammation in both the physiologic environment of the late gestation fetus, and in the neonatal pup.
Tue Apr 28 00:00:00 EDT 2020
Genetic deletion of the Rho GEF Net1 impairs mouse macrophage motility and actin cytoskeletal organization.
Small GTPases
Zuo Y,d'Aigle J,Chauhan A,Frost JA
47-0112 was used in Flow cytometry/Cell sorting to demonstrate that Net1 is an important regulator of RhoA signaling and motility in mouse macrophages in vitro, but that its function may be dispensable for macrophage recruitment to inflammatory sites in vivo.
Wed Jul 01 00:00:00 EDT 2020
Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.
PloS one
Ledo JH,Zhang R,Mesin L,Mourão-Sá D,Azevedo EP,Troyanskaya OG,Bustos V,Greengard P
47-0112 was used in Flow cytometry/Cell sorting to show that PS1 functional connections appear through interaction hubs at Pu.1, Irf8 and Rela-p65 transcription factors.
Tue Oct 13 00:00:00 EDT 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
47-0112 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
47-0112 was used in Flow cytometry/Cell sorting to reveal a function of B7-CD28 co-stimulation in shaping the T cell repertoire and limiting autoimmunity through both thymic clonal deletion and Treg cell generation.
Tue Dec 08 00:00:00 EST 2020
Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells.
Cell reports
Clark NM,Martinez LM,Murdock S,deLigio JT,Olex AL,Effi C,Dozmorov MG,Bos PD
47-0112 was used in Flow cytometry/Cell sorting to highlight the strong myeloid dependency of breast cancer and provide the basis for the development of therapeutic strategies based on manipulation of the IFN-γ signaling pathway in monocytes.
Tue Dec 08 00:00:00 EST 2020
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature
Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC
47-0112-82 was used in Flow Cytometry to develop an immunogen, RC1, that facilitates the recognition of the variable loop 3 (V3)-glycan patch on the envelope protein of HIV-1 to activate B cells that express precursors of broadly neutralizing antibodies within polyclonal repertoires.
Sat Jun 01 00:00:00 EDT 2019
Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Nature
Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D
47-0112-82 was used in Flow Cytometry to show drainage of gut-draining lymph nodes can resolve conflicting tolerogenic and inflammatory intestinal responses by encouraging antigen targeting to specific gut segments.
Wed May 01 00:00:00 EDT 2019
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Cell host & microbe
Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC
47-0112-82 was used in Flow cytometry/Cell sorting to study how skin colonization by commensal Staphylococcus epidermidis facilitates immune tolerance preferentially in neonates via induction of antigen-specific regulatory T cells.
Wed Dec 11 00:00:00 EST 2019
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.
Cell stem cell
Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R
47-0112-82 was used in Flow Cytometry to highlight a critical role of niche-specific effects of Cxcl12 expression in maintaining quiescence of TKI-resistant LSC populations.
Thu May 02 00:00:00 EDT 2019
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.
The Journal of clinical investigation
Abraham A,Qiu S,Chacko BK,Li H,Paterson A,He J,Agarwal P,Shah M,Welner R,Darley-Usmar VM,Bhatia R
47-0112 was used in Flow cytometry/Cell sorting to demonstrate an important role for SIRT1 in leukemia development.
Mon Jun 10 00:00:00 EDT 2019
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges.
The Journal of experimental medicine
Silva HM,Báfica A,Rodrigues-Luiz GF,Chi J,Santos PDA,Reis BS,Hoytema van Konijnenburg DP,Crane A,Arifa RDN,Martin P,Mendes DAGB,Mansur DS,Torres VJ,Cadwell K,Cohen P,Mucida D,Lafaille JJ
47-0112 was used in Flow cytometry/Cell sorting to investigate if tissue-resident macrophages from healthy epididymal white adipose tissue (eWAT), not only surround adipocytes but also associate tightly with blood vessels, being among the most endocytic cells in the body for blood-borne macromolecules.
Mon Apr 01 00:00:00 EDT 2019
Aggregated and Hyperstable Damage-Associated Molecular Patterns Are Released During ER Stress to Modulate Immune Function.
Frontiers in cell and developmental biology
Andersohn A,Garcia MI,Fan Y,Thompson MC,Akimzhanov AM,Abdullahi A,Jeschke MG,Boehning D
47-0112-82 was used in Flow Cytometry to show that induction of chronic ER stress leads to the release of known and novel damage-associated molecular patterns.
Mon Sep 28 00:00:00 EDT 2020
TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
Journal of immunology (Baltimore, Md. : 1950)
Kotov DI,Mitchell JS,Pengo T,Ruedl C,Way SS,Langlois RA,Fife BT,Jenkins MK
47-0112-82 was used in Flow Cytometry to study TCR affinity and influence on regulation of genes in naive T cells that control the differentiation process in cells.
Wed May 01 00:00:00 EDT 2019
Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Barman PK,Pang J,Urao N,Koh TJ
47-0112 was used in Flow cytometry/Cell sorting to investigate whether skin wounding induces monocyte expansion in bone marrow and if IL-1R1 signalling regulates this process.
Wed May 01 00:00:00 EDT 2019
CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity.
Oncology reports
Li Y,Zhao C,Liu J,Lu Z,Lu M,Gu J,Liu R
47-0112 was used in Flow cytometry/Cell sorting to investigate whether CD1d expression on dendritic cells is capable of enhancing anti-tumour immunity, particularly T-cell related immunity.
Wed May 01 00:00:00 EDT 2019
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
47-0112 was used in Flow cytometry/Cell sorting to establish Tpl2 as a critical mediator of MDSC recruitment and highlight the therapeutic potential of Tpl2 for the treatment of fulminant hepatitis (FH).
Wed Oct 14 00:00:00 EDT 2020
Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer.
Frontiers in immunology
Martinez LM,Robila V,Clark NM,Du W,Idowu MO,Rutkowski MR,Bos PD
47-0112-82 was used in Flow cytometry/Cell sorting to investigate Treg cell function in the progression from non-invasive to invasive breast cancer lesions.
Tue Sep 29 00:00:00 EDT 2020
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
47-0112 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.
Thu Sep 05 00:00:00 EDT 2019
Frontline Science: Abnormalities in the gut mucosa of non-obese diabetic mice precede the onset of type 1 diabetes.
Journal of leukocyte biology
Miranda MCG,Oliveira RP,Torres L,Aguiar SLF,Pinheiro-Rosa N,Lemos L,Guimarães MA,Reis D,Silveira T,Ferreira Ê,Moreira TG,Cara DC,Maioli TU,Kelsall BL,Carlos D,Faria AMC
47-0112-82 was used in Flow cytometry/Cell sorting to show that disorders in the intestinal mucosa of NOD mice can potentially interfere with the development of T1D due the close relationship between the gut and the pancreas.
Sun Sep 01 00:00:00 EDT 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
47-0112-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 EDT 2020
Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses.
Cell reports
Cousin C,Oberkampf M,Felix T,Rosenbaum P,Weil R,Fabrega S,Morante V,Negri D,Cara A,Dadaglio G,Leclerc C
47-0112 was used in Flow cytometry/Cell sorting to demonstrate that integrase-deficient lentiviral vectors can trigger persistent adaptive response by the mediation of a weak and transient innate response alongside the persistence of the vector in tissues.
Tue Jan 29 00:00:00 EST 2019
Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4+ T Cells.
Current protocols in immunology
Kotov DI,Jenkins MK
47-0112 was used in Flow cytometry/Cell sorting to study polyclonal epitope-specific CD4+ T cells under physiological conditions.
Sat Jun 01 00:00:00 EDT 2019
Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system.
Communications biology
Xiao C,Wu M,Liu J,Gu J,Jiao X,Lu D,He J,Lin C,Xue Y,Fu T,Wang H,Wang G,Yang X,Li Z
47-0112-82 was used in Flow Cytometry to highlight that the SNS may represent a major molecular sensor and mediator of ATSE-induced inflammation.
Thu Apr 02 00:00:00 EDT 2020
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
47-0112 was used in Flow cytometry/Cell sorting to determine whether haematopoietic stem cell ageing depends on bone marrow innervation by the sympathetic nervous system.
Fri Jun 01 00:00:00 EDT 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
47-0112 was used in Flow cytometry/Cell sorting to reveal a link between mitochondrial function, lysosomal integrity and MHC class I presentation in intestinal epithelial cells.
Thu Jun 28 00:00:00 EDT 2018
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
The Journal of clinical investigation
Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD
47-0112 was used in Flow cytometry/Cell sorting to use human tumour histocultures and syngeneic tumour models treated with Newcastle disease virus to identify immune targets upregulated by OV treatment.
Mon Apr 02 00:00:00 EDT 2018
Insulin resistance causes inflammation in adipose tissue.
The Journal of clinical investigation
Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN
47-0112 was used in Flow cytometry/Cell sorting to elucidate the causal relationship between obesity-induced insulin resistance, and macrophage accumulation and inflammation in adipose tissue.
Mon Apr 02 00:00:00 EDT 2018
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.
The Journal of clinical investigation
Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML
47-0112 was used in Flow cytometry/Cell sorting to study the role of blood growth factors in chronic obstructive pulmonary disease.
Fri Jun 01 00:00:00 EDT 2018
Aging alters the immunological response to ischemic stroke.
Acta neuropathologica
Ritzel RM,Lai YJ,Crapser JD,Patel AR,Schrecengost A,Grenier JM,Mancini NS,Patrizz A,Jellison ER,Morales-Scheihing D,Venna VR,Kofler JK,Liu F,Verma R,McCullough LD
47-0112 was used in Flow cytometry/Cell sorting to study the marked differences in the composition of circulating and infiltrating leukocytes recruited to the ischaemic brain of old male mice after stroke compared to young male mice.
Sun Jul 01 00:00:00 EDT 2018
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.
Molecular therapy : the journal of the American Society of Gene Therapy
Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D
47-0112 was used in Flow cytometry/Cell sorting to study the effects of pre-existing anti-viral immunity on therapeutic efficacy in syngeneic mouse tumour models.
Wed Apr 04 00:00:00 EDT 2018
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.
Scientific reports
Osum KC,Burrack AL,Martinov T,Sahli NL,Mitchell JS,Tucker CG,Pauken KE,Papas K,Appakalai B,Spanier JA,Fife BT
47-0112 was used in Flow cytometry/Cell sorting to suggest that insulin-producing Β cells respond to pancreatic inflammation and IFN-γ production by upregulating PD-L1 expression to limit self-reactive T cells.
Tue May 29 00:00:00 EDT 2018
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Cell reports
Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B
47-0112 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.
Tue Jun 19 00:00:00 EDT 2018
Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.
Nature communications
Yi S,Zhai J,Niu R,Zhu G,Wang M,Liu J,Huang H,Wang Y,Jing X,Kang L,Song W,Shi Y,Tang H
47-0112 was used in Flow cytometry/Cell sorting to suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically.
Mon Sep 24 00:00:00 EDT 2018
Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.
Nature communications
Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG
47-0112 was used in Flow cytometry/Cell sorting to study whether helminth-induced type 2 immunity functionally affects the T virtual memory cell compartment.
Tue Oct 30 00:00:00 EDT 2018
Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus.
Oncotarget
Oseledchyk A,Ricca JM,Gigoux M,Ko B,Redelman-Sidi G,Walther T,Liu C,Iyer G,Merghoub T,Wolchok JD,Zamarin D
47-0112 was used in Flow cytometry/Cell sorting to study the immunogenic potential of an oncolytic virus in bladder cancer where existing immune checkpoint blockade has shown suboptimal response rates.
Tue Jun 19 00:00:00 EDT 2018
CCR7 defines a precursor for murine iNKT cells in thymus and periphery.
eLife
Wang H,Hogquist KA
47-0112 was used in Flow cytometry/Cell sorting to demonstrate that the thymus is both a source of iNKT progenitors and a site of tissue dependent effector cell differentiation.
Mon Aug 13 00:00:00 EDT 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
47-0112 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Cancer cell
Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B
47-0112 was used in Flow cytometry/Cell sorting to demonstrate that the cell surface protein CD276/B7-H3 is broadly over-expressed by multiple tumour types on both cancer cells and tumour-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
Mon Apr 10 00:00:00 EDT 2017
Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response.
Gut
Blasco-Baque V,Garidou L,Pomié C,Escoula Q,Loubieres P,Le Gall-David S,Lemaitre M,Nicolas S,Klopp P,Waget A,Azalbert V,Colom A,Bonnaure-Mallet M,Kemoun P,Serino M,Burcelin R
47-0112 was used in Flow cytometry/Cell sorting to determine the causal mechanism responsible for the enhancement of hyperglycemia and insulin resistance in mice fed a fat-enriched diet.
Mon May 01 00:00:00 EDT 2017
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
The Journal of experimental medicine
Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D
47-0112 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.
Mon May 01 00:00:00 EDT 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
47-0112 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 EDT 2017
Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Weindel CG,Richey LJ,Mehta AJ,Shah M,Huber BT
47-0112 was used in Flow cytometry/Cell sorting to identify that autophagy in B cells and dendritic cells are key to TLR7-mediated autoimmune disorders.
Wed Feb 01 00:00:00 EST 2017
Growth inhibition of formed corneal neovascularization following Fosaprepitant treatment.
Acta ophthalmologica
Bignami F,Lorusso A,Rama P,Ferrari G
47-0112-82 was used in Flow Cytometry to test the efficacy of Neurokinin-1 Receptor (NK-1R) antagonist -Fosaprepitant- in inducing regression of established corneal neovascularization (CNV).
Wed Nov 01 00:00:00 EDT 2017
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors.
Nature communications
Nawaz A,Aminuddin A,Kado T,Takikawa A,Yamamoto S,Tsuneyama K,Igarashi Y,Ikutani M,Nishida Y,Nagai Y,Takatsu K,Imura J,Sasahara M,Okazaki Y,Ueki K,Okamura T,Tokuyama K,Ando A,Matsumoto M,Mori H,Nakagawa T,Kobayashi N,Saeki K,Usui I,Fujisaka S,Tobe K
47-0112 was used in Flow cytometry/Cell sorting to report that M2-like macrophages, create a microenvironment that inhibits proliferation of adipocyte progenitors due to the secretion of TGF-β1.
Fri Aug 18 00:00:00 EDT 2017
Isolation and Identification of Intestinal Myeloid Cells.
Methods in molecular biology (Clifton, N.J.)
Scott CL,Bain CC,Mowat AM
47-0112-82 was used in Flow Cytometry to identify bona fide cDCs, monocytes and macrophages in such preparations.
Wed Jan 31 00:00:00 EST 2018
Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome.
Nature communications
Douam F,Hrebikova G,Albrecht YE,Sellau J,Sharon Y,Ding Q,Ploss A
47-0112 was used in Flow cytometry/Cell sorting to demonstrate the tracking of and sense viral RNA at single-cell resolution within complex subsets of the human and murine immune system in different mouse models.
Tue Mar 14 00:00:00 EDT 2017
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.
Scientific reports
Costa-Gouveia J,Pancani E,Jouny S,Machelart A,Delorme V,Salzano G,Iantomasi R,Piveteau C,Queval CJ,Song OR,Flipo M,Deprez B,Saint-André JP,Hureaux J,Majlessi L,Willand N,Baulard A,Brodin P,Gref R
47-0112 was used in Flow cytometry/Cell sorting to pave the way for a future use of pCD NPs for the pulmonary delivery of the [ETH:Booster] pair in TB chemotherapy.
Fri Jul 14 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
47-0112 was used in Flow cytometry/Cell sorting to highlight that intratumoral immunomodulation with an oncolytic virus expressing a rationally selected ligand can be an effective strategy to drive systemic efficacy of immune checkpoint blockade.
Mon Feb 13 00:00:00 EST 2017
Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo.
mBio
Douam F,Soto Albrecht YE,Hrebikova G,Sadimin E,Davidson C,Kotenko SV,Ploss A
47-0112 was used in Flow cytometry/Cell sorting to analyse the role of type III interferon (IFN)-mediated signaling in controlling the infection and attenuation of the live attenuated yellow virus strain, YFV-17D.
Tue Aug 15 00:00:00 EDT 2017
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
47-0112 was used in Flow cytometry/Cell sorting to suggest that PML-RARA requires DNMT3A to initiate acute promyelocytic leukemia in mice.
Fri Jan 01 00:00:00 EST 2016
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Science translational medicine
Dendrou CA,Cortes A,Shipman L,Evans HG,Attfield KE,Jostins L,Barber T,Kaur G,Kuttikkatte SB,Leach OA,Desel C,Faergeman SL,Cheeseman J,Neville MJ,Sawcer S,Compston A,Johnson AR,Everett C,Bell JI,Karpe F,Ultsch M,Eigenbrot C,McVean G,Fugger L
47-0112 was used in Flow cytometry/Cell sorting to reveal a protective homozygous effect that defined a signalling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for autoimmune disorders.
Wed Nov 02 00:00:00 EDT 2016
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.
Mucosal immunology
Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T
47-0112 was used in Flow cytometry/Cell sorting to investigate the extent to which MyD88 signaling is required to control S. pneumoniae infection, showing that lung epithelium and myeloid cells cooperate to clear infection.
Thu Sep 01 00:00:00 EDT 2016
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.
Oncotarget
Xue W,Brentville VA,Symonds P,Cook KW,Yagita H,Metheringham RL,Durrant LG
47-0112 was used in Flow cytometry/Cell sorting to investigate the anti-tumour effect of a huIgG1 antibody DNA vaccine and PD-1 blockade.
Tue Dec 13 00:00:00 EST 2016
Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
eLife
Yue R,Shen B,Morrison SJ
47-0112 was used in Flow cytometry/Cell sorting to study how Clec11a/Osteolectin maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.
Tue Dec 13 00:00:00 EST 2016
Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells.
PloS one
Kang JO,Lee JB,Chang J
47-0112 was used in Flow cytometry/Cell sorting to determine how cholera toxin skews the differentiation of CD4 T cells to form IL-17-producing Th17 cells.
Tue Aug 08 00:00:00 EDT 2017
Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.
Oncoimmunology
Holmgaard RB,Brachfeld A,Gasmi B,Jones DR,Mattar M,Doman T,Murphy M,Schaer D,Wolchok JD,Merghoub T
47-0112 was used in Flow cytometry/Cell sorting to show that both CSF-1 and its receptor (CSF-1R) are frequently expressed in tumors from cancer patients, and that this expression correlates with tumor-infiltration of MDSCs.
Fri Jul 01 00:00:00 EDT 2016
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
The Journal of experimental medicine
Pallangyo CK,Ziegler PK,Greten FR
47-0112 was used in Flow cytometry/Cell sorting to highlight an unexpected tumor suppressive function of IKKβ/NF-κB in CAFs linked to HGF release.
Mon Dec 14 00:00:00 EST 2015
HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.
Science signaling
Galvani S,Sanson M,Blaho VA,Swendeman SL,Obinata H,Conger H,Dahlbäck B,Kono M,Proia RL,Smith JD,Hla T
47-0112 was used in Flow cytometry/Cell sorting to investigate the role of endothelial cell sphingosine 1-phosphate receptor 1 in adult mice.
Tue Aug 11 00:00:00 EDT 2015
Complement C3 mediated targeting of liposomes to granulocytic myeloid derived suppressor cells.
Nanomedicine : nanotechnology, biology, and medicine
Kullberg M,Martinson H,Mann K,Anchordoquy TJ
47-0112 was used in Flow cytometry/Cell sorting to describe the development of a liposomal drug delivery system which targets immune suppressors.
Sat Aug 01 00:00:00 EDT 2015
Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Reynolds AE,Kuraoka M,Kelsoe G
47-0112 was used in Flow cytometry/Cell sorting to investigate the origin of natural IgM, showing that it is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Thu Jan 01 00:00:00 EST 2015
Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
van Blijswijk J,Schraml BU,Rogers NC,Whitney PG,Zelenay S,Acton SE,Reis e Sousa C
47-0112 was used in Flow cytometry/Cell sorting to report that mice in which DTR is expressed on DCs display lymph node hypocellularity and reduced frequency of DCs in the same organs.
Thu Jan 01 00:00:00 EST 2015
Limited miR-17-92 overexpression drives hematologic malignancies.
Leukemia research
Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E
47-0112 was used in Flow cytometry/Cell sorting to show limited miR-17-92 overexpression can drive hematologic malignancies.
Sun Mar 01 00:00:00 EST 2015
In vivo capture and label-free detection of early metastatic cells.
Nature communications
Azarin SM,Yi J,Gower RM,Aguado BA,Sullivan ME,Goodman AG,Jiang EJ,Rao SS,Ren Y,Tucker SL,Backman V,Jeruss JS,Shea LD
47-0112 was used in Flow cytometry/Cell sorting to develop an in vivo capture and label-free detection method for early metastasis, showing potential to identify metastasis in patients at risk of recurrence.
Tue Sep 08 00:00:00 EDT 2015
Isolation of Mouse Neutrophils.
Current protocols in immunology
Swamydas M,Luo Y,Dorf ME,Lionakis MS
47-0112 was used in Flow cytometry/Cell sorting to describe a reproducible centrifugation-based protocol to harvest highly enriched and highly viable neutrophils from the bone marrow of mice.
Mon Aug 03 00:00:00 EDT 2015
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection.
The Journal of clinical investigation
Olekhnovitch R,Ryffel B,Müller AJ,Bousso P
47-0112 was used in Flow cytometry/Cell sorting to investigate the contribution of cell-intrinsic and cell-extrinsic nitric oxide activity on the control of Leishmania major infection.
Tue Apr 01 00:00:00 EDT 2014
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
The Journal of experimental medicine
Nathanson DA,Armijo AL,Tom M,Li Z,Dimitrova E,Austin WR,Nomme J,Campbell DO,Ta L,Le TM,Lee JT,Darvish R,Gordin A,Wei L,Liao HI,Wilks M,Martin C,Sadeghi S,Murphy JM,Boulos N,Phelps ME,Faull KF,Herschman HR,Jung ME,Czernin J,Lavie A,Radu CG
47-0112 was used in Flow cytometry/Cell sorting to identify dCTP biosynthesis as a potential new therapeutic target for metabolic interventions in haematological malignancies.
Mon Mar 10 00:00:00 EDT 2014
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
The Journal of experimental medicine
Nathanson DA,Armijo AL,Tom M,Li Z,Dimitrova E,Austin WR,Nomme J,Campbell DO,Ta L,Le TM,Lee JT,Darvish R,Gordin A,Wei L,Liao HI,Wilks M,Martin C,Sadeghi S,Murphy JM,Boulos N,Phelps ME,Faull KF,Herschman HR,Jung ME,Czernin J,Lavie A,Radu CG
47-0112 was used in Flow cytometry/Cell sorting to identify dCTP biosynthesis as a potential new therapeutic target for metabolic interventions in haematological malignancies.
Mon Mar 10 00:00:00 EDT 2014
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
The Journal of experimental medicine
Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR
47-0112 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.
Mon Jul 28 00:00:00 EDT 2014
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nature protocols
Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D
47-0112 was used in Flow cytometry/Cell sorting to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.
Wed Jan 01 00:00:00 EST 2014
Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance.
EMBO molecular medicine
Wueest S,Mueller R,Blüher M,Item F,Chin AS,Wiedemann MS,Takizawa H,Kovtonyuk L,Chervonsky AV,Schoenle EJ,Manz MG,Konrad D
47-0112 was used in Flow cytometry/Cell sorting to demonstrate an unanticipated crosstalk between myeloid cells and skeletal muscle in the development of obesity-associated insulin resistance.
Wed Jan 01 00:00:00 EST 2014
Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury.
Cardiovascular research
De Hoog VC,Timmers L,Van Duijvenvoorde A,De Jager SC,Van Middelaar BJ,Smeets MB,Woodruff TM,Doevendans PA,Pasterkamp G,Hack CE,De Kleijn DP
47-0112 was used in Flow cytometry/Cell sorting to demonstrate that selective blocking of C5aR might be a promising strategy to prevent myocardial ischaemia-reperfusion injury.
Mon Sep 01 00:00:00 EDT 2014
Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii.
PLoS pathogens
Dupont CD,Christian DA,Selleck EM,Pepper M,Leney-Greene M,Harms Pritchard G,Koshy AA,Wagage S,Reuter MA,Sibley LD,Betts MR,Hunter CA
47-0112 was used in Flow cytometry/Cell sorting to identify a critical role for actively infected host cells in initiating T. gondii-specific CD4+ and CD8+ T cell responses.
Tue Apr 01 00:00:00 EDT 2014
Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Little MC,Hurst RJ,Else KJ
47-0112 was used in Flow cytometry/Cell sorting to study intestinal inflammation and the dynamic changes in macrophage activation and proliferation that occur during this process.
Sat Nov 01 00:00:00 EDT 2014
Preemptive donor apoptotic cell infusions induce IFN-γ-producing myeloid-derived suppressor cells for cardiac allograft protection.
Journal of immunology (Baltimore, Md. : 1950)
Bryant J,Lerret NM,Wang JJ,Kang HK,Tasch J,Zhang Z,Luo X
47-0112 was used in Flow cytometry/Cell sorting to investigate the role of MDSCs in the graft protection provided by ECDI-SPs, showing that preemptive donor apoptotic cell infusions induce IFN-γ-producing MDSCs.
Sun Jun 15 00:00:00 EDT 2014
GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis.
Journal of immunology (Baltimore, Md. : 1950)
Zhou Q,Ho AW,Schlitzer A,Tang Y,Wong KH,Wong FH,Chua YL,Angeli V,Mortellaro A,Ginhoux F,Kemeny DM
47-0112 was used in Flow cytometry/Cell sorting to identify GM-CSF-licensed CD11b(+) lung DCs as a key component for induction of Th2 responses.
Tue Jul 15 00:00:00 EDT 2014
Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.
Infection and immunity
Christian DA,Koshy AA,Reuter MA,Betts MR,Boothroyd JC,Hunter CA
47-0112 was used in Flow cytometry/Cell sorting to study the cell types which secrete IL-12p40 during Toxoplasma gondii infection.
Wed Oct 01 00:00:00 EDT 2014
Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.
Biochimica et biophysica acta
Winslow V,Vaivoda R,Vasilyev A,Dombkowski D,Douaidy K,Stark C,Drake J,Guilliams E,Choudhary D,Preffer F,Stoilov I,Christmas P
47-0112 was used in Flow cytometry/Cell sorting to conclude that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP enzymes.
Sun Jun 01 00:00:00 EDT 2014
Foxp3 expression in macrophages associated with RENCA tumors in mice.
PloS one
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
47-0112 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 EST 2015
Type 2 innate lymphoid cells control eosinophil homeostasis.
Nature
Nussbaum JC,Van Dyken SJ,von Moltke J,Cheng LE,Mohapatra A,Molofsky AB,Thornton EE,Krummel MF,Chawla A,Liang HE,Locksley RM
47-0112 was used in Flow cytometry/Cell sorting to investigate the processes underlying regulation of cytokine and chemokines for eosinophil development and survival, showing that type 2 innate lymphoid cells control eosinophil homeostasis.
Thu Oct 10 00:00:00 EDT 2013
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
The Journal of clinical investigation
Lionakis MS,Swamydas M,Fischer BG,Plantinga TS,Johnson MD,Jaeger M,Green NM,Masedunskas A,Weigert R,Mikelis C,Wan W,Lee CC,Lim JK,Rivollier A,Yang JC,Laird GM,Wheeler RT,Alexander BD,Perfect JR,Gao JL,Kullberg BJ,Netea MG,Murphy PM
47-0112 was used in Flow cytometry/Cell sorting to elucidate the roles of innate immune cells in the pathogenesis of C. albicans.
Sun Dec 01 00:00:00 EST 2013
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
The Journal of clinical investigation
Zhang H,Neuhöfer P,Song L,Rabe B,Lesina M,Kurkowski MU,Treiber M,Wartmann T,Regnér S,Thorlacius H,Saur D,Weirich G,Yoshimura A,Halangk W,Mizgerd JP,Schmid RM,Rose-John S,Algül H
47-0112 was used in Flow cytometry/Cell sorting to investigate how IL-6 trans-signalling may be an essential mediator of acute lung injury in severe acute pancreatitis.
Fri Mar 01 00:00:00 EST 2013
The Nlrp3 inflammasome regulates acute graft-versus-host disease.
The Journal of experimental medicine
Jankovic D,Ganesan J,Bscheider M,Stickel N,Weber FC,Guarda G,Follo M,Pfeifer D,Tardivel A,Ludigs K,Bouazzaoui A,Kerl K,Fischer JC,Haas T,Schmitt-Gräff A,Manoharan A,Müller L,Finke J,Martin SF,Gorka O,Peschel C,Ruland J,Idzko M,Duyster J,Holler E,French LE,Poeck H,Contassot E,Zeiser R
47-0112 was used in Flow cytometry/Cell sorting to study the establishment and role of the Nlrp3 inflammasome in acute graft-versus-host disease.
Mon Sep 23 00:00:00 EDT 2013
Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia.
The Journal of infectious diseases
Kamei A,Wu W,Traficante DC,Koh AY,Van Rooijen N,Pier GB,Priebe GP
47-0112 was used in Flow cytometry/Cell sorting to investigate the usefulness of vaccine-based strategies to prevent lethal bacterial infection in a host with neutropenia, showing that collaboration between macrophages and vaccine-induced CD4+ T cells confers protection.
Tue Jan 01 00:00:00 EST 2013
Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhu M,Van Dyke TE,Gyurko R
47-0112 was used in Flow cytometry/Cell sorting to evaluate the contribution of the proresolution mediator resolvin E1 (RvE1) on the resolution phase during inflammatory bone disease.
Thu Aug 01 00:00:00 EDT 2013
Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.
The American journal of pathology
Guijarro MV,Dahiya S,Danielson LS,Segura MF,Vales-Lara FM,Menendez S,Popiolek D,Mittal K,Wei JJ,Zavadil J,Cordon-Cardo C,Pandolfi PP,Hernando E
47-0112 was used in Flow cytometry/Cell sorting to elucidate the mechanisms driving cytogenetically complex sarcoma development.
Sat Jun 01 00:00:00 EDT 2013
Differential effects of aging and sex on stroke induced inflammation across the lifespan.
Experimental neurology
Manwani B,Liu F,Scranton V,Hammond MD,Sansing LH,McCullough LD
47-0112 was used in Flow cytometry/Cell sorting to evaluate the relative contribution of several key factors determining stroke outcome.
Fri Nov 01 00:00:00 EDT 2013
CD11b+GR1+ myeloid cells secrete NGF and promote trigeminal ganglion neurite growth: implications for corneal nerve regeneration.
Investigative ophthalmology & visual science
Sarkar J,Chaudhary S,Jassim SH,Ozturk O,Chamon W,Ganesh B,Tibrewal S,Gandhi S,Byun YS,Hallak J,Mahmud DL,Mahmud N,Rondelli D,Jain S
47-0112 was used in Flow cytometry/Cell sorting to study trigeminal ganglion neurites using mice with fluorescent bone marrow cells to show increased growth when CD11b+GR1+ myeloid cells secrete NGF.
Tue Sep 03 00:00:00 EDT 2013
Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice.
Journal of cancer science & therapy
Zheng D,Chen H,Bartee MY,Williams J,Davids JA,Lomas DA,McFadden G,Lucas AR
47-0112 was used in Flow cytometry/Cell sorting to explore the potential use of Serp-1 and M-T7 for treatment of a range of human cancer isolates engrafted in SCID mice.
Mon Aug 19 00:00:00 EDT 2013
Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
The Journal of biological chemistry
Patnode ML,Cheng CW,Chou CC,Singer MS,Elin MS,Uchimura K,Crocker PR,Khoo KH,Rosen SD
47-0112 was used in Flow cytometry/Cell sorting to investigate whether keratan sulfate galactose 6-O-sulfotransferase and chondroitin 6-O-sulfotransferase 1 are required for the generation of endogenous Siglec-F ligands.
Fri Sep 13 00:00:00 EDT 2013
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.
PloS one
Billich A,Baumruker T,Beerli C,Bigaud M,Bruns C,Calzascia T,Isken A,Kinzel B,Loetscher E,Metzler B,Mueller M,Nuesslein-Hildesheim B,Kleylein-Sohn B
47-0112 was used in Flow cytometry/Cell sorting to investigate the involvement of Sgpl1 in models of disease, showing that partial deficiency confers protection in EAE.
Tue Sep 17 00:00:00 EDT 2013
Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea.
European heart journal
Drager LF,Li J,Shin MK,Reinke C,Aggarwal NR,Jun JC,Bevans-Fonti S,Sztalryd C,O'Byrne SM,Kroupa O,Olivecrona G,Blaner WS,Polotsky VY
47-0112 was used in Flow cytometry/Cell sorting to show how chronic intermittent hypoxia may contribute to the atherogenesis observed in obstructive sleep apnoea.
Thu Mar 01 00:00:00 EST 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
47-0112 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
47-0112 was used in Flow cytometry/Cell sorting to investigate a functional link between nucleotide deficiency, replication stress, and two enzymes of the nucleoside salvage pathway: deoxycytidine kinase and thymidine kinase.
Mon Nov 19 00:00:00 EST 2012
A method for quantifying pulmonary Legionella pneumophila infection in mouse lungs by flow cytometry.
BMC research notes
Ang DK,Ong SY,Brown AS,Hartland EL,van Driel IR
47-0112 was used in Flow cytometry/Cell sorting to describe a novel, rapid and versatile method that detects bacteria phagocytosed by neutrophils.
Mon Aug 20 00:00:00 EDT 2012
