Invitrogen

IFN gamma Monoclonal Antibody (4S.B3), Alexa Fluor™ 700, eBioscience™

高级验证

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

78个已发表图片

68 篇参考文献

查看其他185个IFN gamma抗体

说明书

实验方案

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说明书

实验方案

技术支持

IFN gamma Antibody in Flow Cytometry (Flow)

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IFN gamma Antibody (56-7319-42) in Flow

Normal human peripheral blood cells were unstimulated (left) or stimulated for 5 hours with the Cell Stimulation Cocktail (plus protein transport inhibitors) (Product # 00-4975-93) (right). Cells were intracellularly stained with Anti-Human CD4 FITC (Product # 11-0049-42) and Anti-Human IFN gamma Alexa Fluor® 700 using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol. Viable cells in the lymphocyte gate, as determined by Fixable Viability Dye eFluor® 450 (Product # 65-0863-14), were used for anal... View More

IFN gamma Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

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产品信息

56-7319-42

应用

建议稀释比

已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

5 µL (0.25 µg)/test

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酶联免疫吸附实验 (ELISA)

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产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

4S.B3

偶联物

Alexa Fluor™ 700 Alexa Fluor™ 700 Alexa Fluor™ 700

激发/发射光谱

696/719 nm 查看光谱

形式

Liquid

浓度

5 µL/Test

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with 0.2% BSA

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2574509

产品详细信息

Description: The 4S.B3 monoclonal antibody reacts with interferon-gamma (IFN gamma). Human IFN gamma is a 17 kDa factor produced by activated T and NK cells and is an anti-viral and anti-parasitic cytokine. IFN gamma in synergy with other cytokines, such as TNF alpha, inhibits proliferation of normal and transformed cells. Immunomodulatory effects of IFN gamma are exerted on a wide range of cell types expressing the high affinity receptors for IFN gamma. Glycosylation of IFN gamma does not affect its biological activity.

Applications Reported: This 4S.B3 antibody has been reported for use in intracellular staining followed by flow cytometric analysis.

Applications Tested: This 4S.B3 antibody has been pre-titrated and tested by intracellular staining and flow cytometric analysis of stimulated normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol. Please refer to Best Protocols: Protocol A: Two step protocol for (cytoplasmic) intracellular proteins located under the Resources Tab online. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Alexa Fluor® 700 emits at 723 nm and can be excited with the red laser (633 nm). Most instruments will require a 685 LP mirror and 710/20 filter. Please make sure that your instrument is capable of detecting this fluorochrome.

Excitation: 633-647 nm; Emission: 723 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

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Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

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Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

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Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection.

PLoS pathogens

Iampietro M,Younan P,Nishida A,Dutta M,Lubaki NM,Santos RI,Koup RA,Katze MG,Bukreyev A

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes.

Journal of extracellular vesicles

Salimu J,Webber J,Gurney M,Al-Taei S,Clayton A,Tabi Z

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.

JCI insight

Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Thu Aug 03 00:00:00 EDT 2017

Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.

Oncotarget

Pathangey LB,McCurry DB,Gendler SJ,Dominguez AL,Gorman JE,Pathangey G,Mihalik LA,Dang Y,Disis ML,Cohen PA

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2017

CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.

Molecular medicine reports

Tang ZS,Hao YH,Zhang EJ,Xu CL,Zhou Y,Zheng X,Yang DL

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.

PloS one

Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Tue Jul 19 00:00:00 EDT 2016

Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells.

Oncoimmunology

Seebauer CT,Brunner S,Glockzin G,Piso P,Ruemmele P,Schlitt HJ,Geissler EK,Fichtner-Feigl S,Kesselring R

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes.

Nucleic acids research

Zhong F,Zhou N,Wu K,Guo Y,Tan W,Zhang H,Zhang X,Geng G,Pan T,Luo H,Zhang Y,Xu Z,Liu J,Liu B,Gao W,Liu C,Ren L,Li J,Zhou J,Zhang H

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2015

Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Moon EK,Wang LC,Dolfi DV,Wilson CB,Ranganathan R,Sun J,Kapoor V,Scholler J,Puré E,Milone MC,June CH,Riley JL,Wherry EJ,Albelda SM

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Fri Aug 15 00:00:00 EDT 2014

Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.

mAbs

Thaventhiran T,Alhumeed N,Yeang HX,Sethu S,Downey JS,Alghanem AF,Olayanju A,Smith EL,Cross MJ,Webb SD,Williams DP,Bristow A,Ball C,Stebbings R,Sathish JG

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Mon Aug 24 00:00:00 EDT 2015

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma.

Oncotarget

Ye SB,Li ZL,Luo DH,Huang BJ,Chen YS,Zhang XS,Cui J,Zeng YX,Li J

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Wed Jul 30 00:00:00 EDT 2014

Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome.

PloS one

Zhang L,Wang T,Wang XQ,Du RZ,Zhang KN,Liu XG,Ma DX,Yu S,Su GH,Li ZH,Guan YQ,Du NL

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Mon Aug 18 00:00:00 EDT 2014

Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis.

PloS one

Zhang L,Li YG,Li YH,Qi L,Liu XG,Yuan CZ,Hu NW,Ma DX,Li ZF,Yang Q,Li W,Li JM

Published figure using IFN gamma monoclonal antibody (Product # 56-7319-42) in Flow Cytometry

Fri Jul 27 00:00:00 EDT 2012

生物信息学

蛋白别名: H-IFN-g; IFN γ; IFN-gamma; IFN-y; IFNγ; Immune interferon; Interferon; Interferon gamma; Interferon y; Interferon γ; interferon, gamma; Interferonγ; M-IFN-g; R-IFN-g

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基因别名: IFG; IFI; IFNG

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UniProt ID: (Human) P01579

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Entrez Gene ID: (Human) 3458

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功能

cytokine activity interferon-gamma receptor binding cytokine interferon superfamily intercellular signal molecule

参与通路