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5HT2A Receptor (HTR2A) (extracellular) Antibody (ASR-033-200UL) in IHC (F)
Expression of5HT2A Receptorin ratcingulatecortex. Immunohistochemicalstaining of perfusion-fixed frozen rat brain sections with Anti-5HT2A Receptor (HTR2A) (extracellular) Antibody (#ASR-033), (1:1200), followed by goat Anti-rabbit-AlexaFluor-488.A.5HT2A Receptorimmunoreactivity (green) appearsinoutlines of cortical neurons (arrows).B. Pre-incubation of the Antibody with 5HT2A Receptor (HTR2A) (extracellul... View More
产品信息
ASR-033-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)SEASNWTIDAENR, corresponding to amino acid residues 40-52 of rat 5-Hydroxytryptamine receptor 2A, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-HT-2; 5-HT-2A; 5-HT2 receptor; 5-HT2A receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; serotonin 5-HT-2A receptor; serotonin 5HT-2 receptor; Serotonin receptor 2A; SR2A
基因别名: 5-HT2A; 5Ht-2; E030013E04; Htr-2; HTR2; HTR2A
UniProt ID: (Human) P28223, (Mouse) P35363, (Rat) P14842
Entrez Gene ID: (Human) 3356, (Mouse) 15558, (Rat) 29595
virus receptor activity
G-protein alpha-subunit binding
G-protein coupled serotonin receptor activity
drug binding
protein complex binding
serotonin binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
signal transducer activity
G-protein coupled receptor activity
protein binding
G-protein coupled receptor
temperature homeostasis
cellular calcium ion homeostasis
activation of phospholipase C activity
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
aging
memory
cell death
positive regulation of cell proliferation
positive regulation of phosphatidylinositol biosynthetic process
regulation of dopamine secretion
phosphatidylinositol 3-kinase signaling
artery smooth muscle contraction
urinary bladder smooth muscle contraction
sleep
response to drug
negative regulation of potassium ion transport
positive regulation of MAP kinase activity
protein localization to cytoskeleton
positive regulation of fat cell differentiation
positive regulation of glycolytic process
positive regulation of vasoconstriction
viral entry into host cell
regulation of hormone secretion
behavioral response to cocaine
positive regulation of peptidyl-tyrosine phosphorylation
regulation of behavior
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
release of sequestered calcium ion into cytosol
negative regulation of synaptic transmission, glutamatergic
positive regulation of ERK1 and ERK2 cascade
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
behavior
sensory perception of pain
positive regulation of kinase activity
