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Immunogen sequence: GHRFCDTCL QEFLSEGVFK CPEDQLPLDY AKIYPDPELE VQVLGLPIRC IHSEEGCRWS GPLRHLQGHL NTCSFNVIPC PNRCPMKLSR RDLPAHLQHD CPKRRLKCEF CGCDFSGEAY ESHEGMCPQE SVYCENKCGA RMMRRLLAQH ATSECPKRTQ PCTYCTKEFV FDTIQSHQYQ CPRLPVACPN QCGVGTVARE DLPGHLKDSC NTALVLCPFK DSGCKHRCPK LAMARHVEES VKPHLAMMCA LVSRQRQELQ ELRRELEELS VGSD (35-307 aa encoded by BC001769)
The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine rich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40. Ligands for these receptors can be small, secreted proteins, such as TNF, or type II integral membrane proteins, as is the case for the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 have been shown to induce the nuclear translocation of NFkB. Members of the TRAF (TNF receptor-associated factor) family have been implicated in this process. Four members have thus far been described and are designated TRAF1, TRAF2, TRAF3 (variously referred to as CRAF1, LAP1 or CD40bp) and TRAF4. TRAF4, originally termed CART1, is specifically expressed in breast carcinomas, and is localized to the nucleus in such tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cysteine-rich domain associated with ring and TRAF domain; Cysteine-rich domain associated with RING and Traf domains protein 1; malignant 62; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83; RNF83malignant 62; TNF receptor-associated factor 4; TRAF4 variant 6; tumor necrosis receptor-associated factor 4A
基因别名: CART1; MLN62; RNF83; TRAF4
UniProt ID: (Human) Q9BUZ4
Entrez Gene ID: (Pig) 100518396, (Human) 9618