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Antibodies Inc
Copper ATPase 1 (Menke's Disease Protein) Monoclonal Antibody (L60/4)
Product Details
75-142
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
L60/4
Immunogen
Synthetic peptide amino acids 42-61 (cytoplasmic N- terminus) of human Copper-transporting ATPase 1 (accession number Q04656).
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP 7A; ATPase, Cu++ transporting, alpha polypeptide; Copper pump 1; Copper-transporting ATPase 1; Cu++-transporting P-type ATPase; FLJ17790; MC 1; Menke; Menkes disease-associated protein; Menkes disease-associated protein homolog; Menkes protein; Menkes syndrome; OHS; OTTHUMP00000062077
Gene Aliases: ATP7A; DSMAX; MC1; MK; MNK; SMAX3
UniProt ID: (Human) Q04656, (Mouse) Q64430, (Rat) P70705
Entrez Gene ID: (Human) 538, (Mouse) 11977, (Rat) 24941
copper-exporting ATPase activity
copper ion transmembrane transporter activity
copper ion binding
protein binding
ATP binding
superoxide dismutase copper chaperone activity
copper-dependent protein binding
nucleotide binding
hydrolase activity
cation-transporting ATPase activity
metal ion binding
molecular_function
primary active transporter
blood vessel development
in utero embryonic development
blood vessel remodeling
regulation of oxidative phosphorylation
tryptophan metabolic process
catecholamine metabolic process
copper ion transport
cellular copper ion homeostasis
mitochondrion organization
lactation
locomotory behavior
response to iron(III) ion
response to zinc ion
detoxification of copper ion
copper ion import
plasma membrane copper ion transport
peptidyl-lysine modification
removal of superoxide radicals
cerebellar Purkinje cell differentiation
pyramidal neuron development
central nervous system neuron development
extracellular matrix organization
collagen fibril organization
hair follicle morphogenesis
ion transmembrane transport
T-helper cell differentiation
epinephrine metabolic process
norepinephrine metabolic process
dopamine metabolic process
serotonin metabolic process
positive regulation of catalytic activity
negative regulation of catalytic activity
pigmentation
skin development
elastic fiber assembly
lung alveolus development
neuron projection morphogenesis
cartilage development
positive regulation of oxidoreductase activity
elastin biosynthetic process
copper ion export
release of cytochrome c from mitochondria
tyrosine metabolic process
transport
ion transport
cation transport
regulation of gene expression
metal ion transport
hindlimb morphogenesis
norepinephrine biosynthetic process
negative regulation of neuron apoptotic process
ATP metabolic process
response to copper ion
dendrite morphogenesis
Performance Guarantee
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