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Antibodies Inc
Neurexin-1-Beta Monoclonal Antibody (N170A/1), FL490
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Product Details
75-216-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N170A/1
Immunogen
Synthetic peptide amino acids 47-64 of rat Neurexin-1-Beta (accession number Q63373).
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: ASSLGAHHIH HFHGSSKH
Target Information
Neurexin-1-beta (NRXN1-beta) is a gene that encodes the beta-isoform of the neurexin-1 protein, which is a type I membrane protein that functions as a cell adhesion molecule and receptor in the nervous system. Located on chromosome 2 in humans, the neurexin-1 gene undergoes complex alternative splicing, producing multiple isoforms, including the well-studied alpha-neurexin and beta-neurexin. Neurexins, including NRXN1-beta, are primarily involved in synapse formation and function by mediating interactions between presynaptic and postsynaptic neurons. They bind to neuroligins, another family of cell adhesion molecules, thus playing a critical role in the maintenance and regulation of synaptic specificity and neurotransmitter release. Dysregulation or mutations in NRXN1-beta have been implicated in various neurological and psychiatric disorders, including autism spectrum disorders, schizophrenia, and intellectual disabilities, emphasizing the importance of this gene in brain development and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-latrotoxin receptor (calcium-dependent); neurexin 1; neurexin I; Neurexin I-alpha; Neurexin I-beta; Neurexin-1; Neurexin-1-alpha; Neurexin-1-beta; non-processed neurexin I-alpha
Gene Aliases: 1700062G21Rik; 9330127H16Rik; A230068P09Rik; Hs.22998; KIAA0578; mKIAA0578; NRXN1; Nrxn1b; PTHSL2; SCZD17
UniProt ID: (Human) Q9ULB1, (Mouse) Q9CS84, (Rat) Q63372
Entrez Gene ID: (Human) 9378, (Mouse) 18189, (Rat) 60391
vesicle docking involved in exocytosis
cell adhesion
signal transduction
chemical synaptic transmission
neurotransmitter secretion
synapse assembly
learning
adult behavior
social behavior
vocal learning
neuromuscular process controlling balance
protein heterotetramerization
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
prepulse inhibition
regulation of insulin secretion involved in cellular response to glucose stimulus
vocalization behavior
positive regulation of synapse maturation
postsynaptic membrane assembly
gephyrin clustering involved in postsynaptic density assembly
neuroligin clustering involved in postsynaptic membrane assembly
postsynaptic density protein 95 clustering
positive regulation of excitatory postsynaptic potential
regulation of grooming behavior
angiogenesis
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
neuron cell-cell adhesion
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cerebellar granule cell differentiation
protein localization to synapse
establishment of protein localization
negative regulation of filopodium assembly
positive regulation of establishment of protein localization to plasma membrane
protein complex assembly involved in synapse maturation
synaptic vesicle clustering
presynaptic membrane assembly
gamma-aminobutyric acid receptor clustering
NMDA glutamate receptor clustering
guanylate kinase-associated protein clustering
receptor localization to synapse
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
axon guidance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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