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Antibodies Inc
KA2 Kainate Receptor Monoclonal Antibody (N279B/27), FL490
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Product Details
75-362-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N279B/27
Immunogen
Fusion protein amino acids 825-979 (cytoplasmic C-terminus) of rat KA2 kainate receptor (accession number Q63273) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluK5; GluR gamma-2; glutamate receptor; Glutamate receptor gamma-2; Glutamate receptor ionotropic, kainate 5; Glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor, ionotropic kainate 5; KA2
Gene Aliases: GluK5; GluRgamma2; Grik5; iGlu5; KA2
UniProt ID: (Rat) Q63273, (Mouse) Q61626
Entrez Gene ID: (Rat) 24407, (Mouse) 14809
extracellular-glutamate-gated ion channel activity
protein binding
glutamate receptor activity
kainate selective glutamate receptor activity
SH3 domain binding
PDZ domain binding
identical protein binding
receptor activity
ionotropic glutamate receptor activity
ion channel activity
transmembrane signal receptor
protein retention in ER lumen
signal transduction
chemical synaptic transmission
regulation of synaptic vesicle fusion to presynaptic membrane
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
receptor clustering
positive regulation of neuron apoptotic process
establishment of localization in cell
excitatory postsynaptic potential
cellular response to glucose stimulus
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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