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ABCA7 Antibody (MA5-24784) in WB
Western blot analysis of ABCA7 in mouse platelets. Samples were incubated in ABCA7 monoclonal antibody (Product # MA5-24784) using a dilution of 0.5 µg/mL followed by an anti-rat HRP secondary antibody. Separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. Detection: chemiluminescence.
产品信息
MA5-24784
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
7A1-144
抗原
Mouse ABCA7 stably-transfected HeLa cells.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2717257
靶标信息
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABC 1 antibody; ABC Transporter 1; ABC1; ABC1 antibody; ATP-binding cassette sub-family A member 7; CERP; CERP antibody; EC 2.2.1.1; EC 3.6.3; EC 3.6.3.41; FLJ40025
基因别名: Abc51; Abca7; ABCX
UniProt ID: (Mouse) Q91V24
Entrez Gene ID: (Mouse) 27403
nucleotide binding
transporter activity
protein binding
ATP binding
phospholipid transporter activity
ATPase activity
cholesterol transporter activity
apolipoprotein A-I receptor activity
ATPase activity, coupled to transmembrane movement of substances
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
transport
phagocytosis
memory
positive regulation of cholesterol efflux
phospholipid scrambling
peptide cross-linking
negative regulation of ATPase activity
positive regulation of ATPase activity
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle assembly
protein localization to nucleus
apolipoprotein A-I-mediated signaling pathway
negative regulation of amyloid precursor protein biosynthetic process
positive regulation of phagocytosis
transmembrane transport
positive regulation of ERK1 and ERK2 cascade
positive regulation of beta-amyloid clearance
positive regulation of engulfment of apoptotic cell
negative regulation of beta-amyloid formation
positive regulation of phospholipid efflux
