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产品信息
PA5-102882
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ABCG1(Accession P45844), corresponding to amino acid residues E191-D241.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852265
产品详细信息
Antibody detects endogenous levels of total ABCG1.
靶标信息
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABC transporter 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub-family G (WHITE), member 1; homolog of Drosophila white; MGC34313; White protein homolog; white protein homolog (ATP-binding cassette transporter 8)
基因别名: ABC8; ABCG1; WHITE1; WHT1
UniProt ID: (Human) P45844
Entrez Gene ID: (Human) 9619
ATP binding
phospholipid binding
phospholipid transporter activity
cholesterol binding
cholesterol transporter activity
toxin transporter activity
sterol-transporting ATPase activity
glycoprotein transporter activity
protein homodimerization activity
ADP binding
protein heterodimerization activity
protein dimerization activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
regulation of transcription, DNA-templated
cholesterol metabolic process
detection of hormone stimulus
response to organic substance
negative regulation of macrophage derived foam cell differentiation
regulation of cholesterol esterification
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
intracellular cholesterol transport
cholesterol efflux
phospholipid efflux
response to lipid
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
glycoprotein transport
lipoprotein metabolic process
cholesterol homeostasis
amyloid precursor protein catabolic process
reverse cholesterol transport
positive regulation of cholesterol biosynthetic process
transmembrane transport
phospholipid homeostasis
response to high density lipoprotein particle
toxin transport
