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ACSL5 Antibody (PA5-89639) in WB
Western blot analysis of ACSL5 in extracts of various cell lines. Samples were incubated with ACSL5 Polyclonal antibody (Product # PA5-89639) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
PA5-89639
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 500-739 of human ACSL5 (NP_0573182)
偶联物
形式
Liquid
浓度
0.74 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805705
产品详细信息
Immunogen sequence: GQTECTGGCT FTLPGDWTSG HVGVPLACNY VKLEDVADMN YFTVNNEGEV CIKGTNVFKG YLKDPEKTQE ALDSDGWLHT GDIGRWLPNG TLKIIDRKKN IFKLAQGEYI APEKIENIYN RSQPVLQIFV HGESLRSSLV GVVVPDTDVL PSFAAKLGVK GSFEELCQNQ VVREAILEDL QKIGKESGLK TFEQVKAIFL HPEPFSIENG LLTPTLKAKR GELSKYFRTQ IDSLYEHIQD; Positive Samples: HL-60, Mouse liver, Rat liver; Cellular Location: Endoplasmic reticulum, Endoplasmic reticulum membrane, Mitochondrion, Mitochondrion outer membrane, Single-pass type III membrane protein
靶标信息
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arachidonate--CoA ligase; FACL5 for fatty acid coenzyme A ligase 5; fatty acid coenzyme A ligase 5; fatty acid Coenzyme A ligase, long chain 5; fatty-acid-Coenzyme A ligase, long-chain 5; HGNC:16526; LACS 5; Long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; Long-chain-fatty-acid--CoA ligase 5
基因别名: 1700030F05Rik; ACS2; ACS5; ACSL5; FACL5; UNQ633/PRO1250
UniProt ID: (Human) Q9ULC5, (Rat) O88813, (Mouse) Q8JZR0
Entrez Gene ID: (Human) 51703, (Rat) 94340, (Mouse) 433256
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
fatty acid metabolic process
response to nutrient
metabolic process
phospholipid biosynthetic process
response to sucrose
response to glucose
positive regulation of plasma membrane long-chain fatty acid transport
positive regulation of triglyceride biosynthetic process
fatty acid transport
positive regulation of fatty acid beta-oxidation
cellular response to insulin stimulus
response to cholesterol
regulation of extrinsic apoptotic signaling pathway
lipid metabolic process
