Invitrogen

ACSL6 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他5个ACSL6抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (3)
高级验证 (1)

ACSL6 Antibody in Immunohistochemistry (IHC)

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ACSL6 Antibody (PA5-59191) in IHC

Immunohistochemical staining of ACSL6 in human testis and skin tissues using ACSL6 Polyclonal Antibody (Product # PA5-59191). Corresponding ACSL6 RNA-seq data are presented for the same tissues.

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ACSL6 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of ACSL6 demonstrates antibody specificity. Immunohistochemical analysis of ACSL6 using anti-ACSL6 Polyclonal Antibody (Product # PA5-59191), shows significant staining of ACSL6 in human testis and shows minimal or weak staining in human skin tissues. The relative expression levels of ACSL6 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-59191

应用

建议稀释比

已发表文章

免疫组化 (IHC)

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human ACSL6. Recombinant protein control fragment (Product #RP-89595).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2637625

产品详细信息

Immunogen sequence: RYIINTADIS TVIVDKPQKA VLLLEHVERK ETPGLKLIIL MDPFEEALKE RGQKCGVVIK SMQAVEDCGQ ENHQAPVPPQ PDDLSIVCFT SGTTGNPKGA MLTHGNVVAD F

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.

靶标信息

FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t(5;12)(q31;p13) that involves ETV6 and ACSL6.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Arachidonate--CoA ligase; fatty-acid-Coenzyme A ligase, long-chain 6; L LACS5; LACS 6; long fatty acyl-CoA synthetase 2; Long-chain acyl-CoA synthetase 6; Long-chain-fatty-acid--CoA ligase 6

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基因别名: ACS2; ACSL6; FACL6; KIAA0837; LACS 6; LACS2; LACS5

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UniProt ID: (Human) Q9UKU0

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Entrez Gene ID: (Human) 23305

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功能

long-chain fatty acid-CoA ligase activity ATP binding protein homodimerization activity decanoate--CoA ligase activity ligase

参与通路

long-chain fatty acid metabolic process acyl-CoA metabolic process long-chain fatty-acyl-CoA biosynthetic process