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产品信息
PA5-99052
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Long-chain-fatty-acid--CoA ligase 6 protein (458-697AA)
偶联物
形式
Liquid
浓度
0.46 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2813665
靶标信息
FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t(5;12)(q31;p13) that involves ETV6 and ACSL6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 6; fatty-acid-Coenzyme A ligase, long-chain 6; L LACS5; LACS 6; long fatty acyl-CoA synthetase 2; Long-chain acyl-CoA synthetase 6; Long-chain-fatty-acid--CoA ligase 6
基因别名: A330035H04Rik; ACS2; ACSL6; AW050338; FACL6; KIAA0837; LACS; LACS 6; LACS2; LACS5; Lacsl; mKIAA0837
UniProt ID: (Human) Q9UKU0, (Mouse) Q91WC3
Entrez Gene ID: (Human) 23305, (Mouse) 216739
long-chain fatty acid metabolic process
acyl-CoA metabolic process
long-chain fatty-acyl-CoA biosynthetic process
lipid metabolic process
fatty acid metabolic process
triglyceride metabolic process
neuroblast proliferation
metabolic process
phospholipid biosynthetic process
positive regulation of plasma membrane long-chain fatty acid transport
positive regulation of triglyceride biosynthetic process
positive regulation of neuron projection development
fatty acid transport
