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产品信息
PA1-41185
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 475-525 of human ACVR1.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 0.2% gelatin
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2305086
产品详细信息
By Western blot, this antibody detects a ~54 kDa band representing Activin Receptor Type IA.
Additional non-specific bands at ~14 and 27 kDa may also be detected in human kidney samples.
Suggested positive control: human kidney protein or tissue.
靶标信息
Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I
基因别名: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI
UniProt ID: (Human) Q04771, (Rat) P80201, (Mouse) P37172
Entrez Gene ID: (Human) 90, (Rat) 79558, (Mouse) 11477
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
activin receptor activity, type I
peptide hormone binding
protein homodimerization activity
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
growth factor binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
G1/S transition of mitotic cell cycle
patterning of blood vessels
in utero embryonic development
gastrulation with mouth forming second
mesoderm formation
neural crest cell migration
acute inflammatory response
embryonic heart tube morphogenesis
outflow tract septum morphogenesis
atrioventricular valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
endocardial cushion fusion
atrial septum primum morphogenesis
protein phosphorylation
transforming growth factor beta receptor signaling pathway
germ cell development
determination of left/right symmetry
negative regulation of signal transduction
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
regulation of ossification
positive regulation of cell migration
positive regulation of bone mineralization
BMP signaling pathway
activin receptor signaling pathway
negative regulation of activin receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
pharyngeal system development
pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
cardiac muscle cell fate commitment
BMP signaling pathway involved in heart development
endocardial cushion cell fate commitment
cellular response to glucocorticoid stimulus
cellular response to BMP stimulus
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of determination of dorsal identity
negative regulation of extrinsic apoptotic signaling pathway
urogenital system development
gastrulation
mesoderm development
heart development
regulation of skeletal muscle tissue development
transmembrane receptor protein serine/threonine kinase signaling pathway
embryo development
phosphorylation
intracellular signal transduction
