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产品信息
PA1-28007
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
recombinant human activin receptor IB expressed in mouse NSO cells
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2305104
产品详细信息
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin A receptor type IB; activin A receptor, type IB; activin A receptor, type II-like kinase 4; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR-IB; ACTRI; ACVR1A; ACVRLK2; ALK-4; ALK2; FOP; Serine/threonine-protein kinase receptor R2; SKR2; TSRI
基因别名: ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2
UniProt ID: (Human) P36896
Entrez Gene ID: (Human) 91
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
activin receptor activity, type I
activin-activated receptor activity
growth factor binding
ubiquitin protein ligase binding
inhibin binding
SMAD binding
metal ion binding
activin binding
serine/threonine protein kinase receptor
G1/S transition of mitotic cell cycle
in utero embryonic development
hair follicle development
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
central nervous system development
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
negative regulation of cell growth
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
nodal signaling pathway
positive regulation of erythrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
development of primary female sexual characteristics
protein autophosphorylation
extrinsic apoptotic signaling pathway
positive regulation of trophoblast cell migration
