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产品信息
PA5-48090
产品规格
种属反应
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant rat ALK-7 Leu26-Arg108 (predicted)
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608290
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
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生物信息学
蛋白别名: Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACTRI; ACVR1A; acvr1c {ECO:0000312|EMBL:AAC52803.1}; ACVRLK2; ALK-7; ALK2; FOP; TGF-beta type 1 receptor; TSRI
基因别名: Acvr1c; Alk-7; Alk7; habrec1
UniProt ID: (Rat) P70539
Entrez Gene ID: (Rat) 245921
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
ATP binding
activin receptor activity, type I
growth factor binding
nodal binding
SMAD binding
metal ion binding
activin binding
BMP receptor binding
serine/threonine protein kinase receptor
ovarian follicle development
in utero embryonic development
response to dietary excess
protein phosphorylation
apoptotic process
transforming growth factor beta receptor complex assembly
determination of left/right symmetry
response to glucose
response to organic cyclic compound
lipid storage
cerebellum development
hippocampus development
signal transduction by protein phosphorylation
cell differentiation
apoptotic nuclear changes
midbrain development
response to insulin
activin receptor signaling pathway
response to lipid
nodal signaling pathway
response to drug
regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of insulin secretion
negative regulation of trophoblast cell migration
negative regulation of chorionic trophoblast cell proliferation
