Invitrogen

ACVR2A Polyclonal Antibody

查看其他12个ACVR2A抗体
说明书
实验方案
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说明书
实验方案
技术支持

产品信息

PA5-114823

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human ACVR2A(Accession P27037), corresponding to amino acid residues V284-L334.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2899459

产品详细信息

Antibody detects endogenous levels of total ACVR2A.

靶标信息

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: activin A receptor type IIA; activin A receptor, type IIA; activin receptor IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA; type II activin receptor

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基因别名: ACTRII; ActrIIa; ACVR2; ACVR2A; rActR-II; TactrII

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UniProt ID: (Human) P27037, (Rat) P38444, (Mouse) P27038

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Entrez Gene ID: (Human) 92, (Rat) 29263, (Mouse) 11480

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功能
protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding coreceptor activity activin-activated receptor activity growth factor binding PDZ domain binding inhibin binding protein self-association metal ion binding activin binding BMP receptor activity transforming growth factor beta-activated receptor activity activin receptor activity, type II nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
参与通路
gastrulation with mouth forming second positive regulation of protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway spermatogenesis determination of left/right symmetry mesoderm development anterior/posterior pattern specification positive regulation of pathway-restricted SMAD protein phosphorylation signal transduction by protein phosphorylation positive regulation of bone mineralization BMP signaling pathway regulation of BMP signaling pathway activin receptor signaling pathway positive regulation of activin receptor signaling pathway sperm ejaculation penile erection positive regulation of erythrocyte differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system development regulation of nitric-oxide synthase activity Sertoli cell proliferation cellular response to BMP stimulus protein phosphorylation male gonad development regulation of signal transduction response to organic substance positive regulation of follicle-stimulating hormone secretion phosphorylation
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