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ACVR2A Antibody (PA5-22325) in WB
Activin A Receptor type IIA antibody detects Activin A Receptor type IIA protein by Western blot analysis. Whole cell extracts (30 µg) was separated by 10% SDS-PAGE, and the membrane was blotted with Activin A Receptor type IIA antibody ACVR2A Polyclonal Antibody (Product # PA5-22325) diluted by 1:4,000.
产品信息
PA5-22325
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 267 and 513 of Activin A Receptor type IIA (Uniprot ID#P27037)
偶联物
Unconjugated
形式
Liquid
浓度
0.86 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154389
产品详细信息
Recommended positive controls: HeLa, HepG2.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (94%), Pig (99%), Chicken (96%), Sheep (98%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin A receptor type IIA; activin A receptor, type IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA
基因别名: ACTRII; ACVR2; ACVR2A
UniProt ID: (Human) P27037
Entrez Gene ID: (Human) 92
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
coreceptor activity
activin-activated receptor activity
growth factor binding
PDZ domain binding
inhibin binding
protein self-association
metal ion binding
activin binding
BMP receptor activity
serine/threonine protein kinase receptor
gastrulation with mouth forming second
positive regulation of protein phosphorylation
transmembrane receptor protein serine/threonine kinase signaling pathway
spermatogenesis
determination of left/right symmetry
mesoderm development
anterior/posterior pattern specification
positive regulation of pathway-restricted SMAD protein phosphorylation
signal transduction by protein phosphorylation
positive regulation of bone mineralization
BMP signaling pathway
regulation of BMP signaling pathway
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
sperm ejaculation
penile erection
positive regulation of erythrocyte differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system development
regulation of nitric-oxide synthase activity
Sertoli cell proliferation
cellular response to BMP stimulus
