Invitrogen

ACVR2A Monoclonal Antibody (A7C8)

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ACVR2A Antibody (MA5-50611) in WB

Western blot analysis of ACVR2A in different various lysates. Lane 1: K562 cell lysate; Lane 2: HepG2 cell lysate Lysates/proteins at 10 µg/Lane. Predicted band size: 58 kDa. Observed band size: 50 kDa. Exposure time: 1 minute;10% SDS-PAGE gel. Primary antibody ACVR2A monoclonal antibody (Product # MA5-50611) with a dilution of 1:1,000 was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Mouse IgG-HRP Secondary Antibody with a dilution of 1:300,000 was used for 1 hour at room temperature. Proteins were transferred to a PVDF ... View More

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产品信息

MA5-50611

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

A7C8

抗原

Synthetic peptide within Human ACVR2A aa 464-513/513.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_3091320

产品详细信息

Positive control: K562 cell lysate, HepG2 cell lysate.

Predicted band size: 58 kDa

Subcellular Location: Membrane.

靶标信息

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

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