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产品信息
H00000118-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2C9
抗原
ADD1 (AAH42998, 1 a.a. approximately 662 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQDAPLS DCTETIEGLE LTEQTFSPAK SLSFRKGELV TASKAIIEKE YQPHVIVSTT GPNPFTTLTD RELEEYRREV ERKQKGSEEN LDEAREQKEK SPPDQPAVPH PPPSTPIKLE EGDGCAREYL LP
靶标信息
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADD2; ADDB; adducin 1 (alpha); Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; Alpha-adducin; beta Adducin; erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha
基因别名: ADD1; ADDA
UniProt ID: (Human) P35611
Entrez Gene ID: (Human) 118
actin binding
structural molecule activity
calmodulin binding
transcription factor binding
spectrin binding
protein homodimerization activity
poly(A) RNA binding
protein heterodimerization activity
actin filament binding
cadherin binding involved in cell-cell adhesion
non-motor actin binding protein
cell morphogenesis
in utero embryonic development
cell volume homeostasis
hemoglobin metabolic process
actin cytoskeleton organization
erythrocyte differentiation
positive regulation of protein binding
multicellular organism growth
IRE1-mediated unfolded protein response
homeostasis of number of cells within a tissue
barbed-end actin filament capping
actin filament bundle assembly
transmembrane transport
cell-cell adhesion
