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产品信息
PA5-61811
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2637813
产品详细信息
Immunogen sequence: SHSATKSALI QKLMQDIQHQ DNYEAIWEKI EGFVNKLDEF IQWLNEAMET TENWTPPKAE MDDLKLYLET HLSFKLNVDS HCALKEAVEE EGHQLLELIA SHKAGLKDML RMIASQWKEL QRQIKRQHSW ILRALDTIKA
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 93%.
靶标信息
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.
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生物信息学
蛋白别名: A kinase (PRKA) anchor protein 6; A-kinase anchor protein 100 kDa; A-kinase anchor protein 6; AKAP 100; AKAP-6; mAKAP; PRKA6; protein kinase A anchoring protein 6; Protein kinase A-anchoring protein 6
基因别名: ADAP100; ADAP6; AKAP100; AKAP6; KIAA0311; mAKAP; PRKA6
UniProt ID: (Human) A7E2D4
Entrez Gene ID: (Human) 9472
action potential
protein targeting
regulation of protein kinase A signaling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cAMP-mediated signaling
positive regulation of cell growth
negative regulation of cAMP biosynthetic process
positive regulation of protein phosphatase type 2B activity
intracellular signal transduction
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of NFAT protein import into nucleus
regulation of membrane repolarization
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of calcineurin-NFAT signaling cascade
cellular response to cAMP
cellular response to cytokine stimulus
positive regulation of potassium ion transmembrane transport
positive regulation of delayed rectifier potassium channel activity
