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产品信息
PA5-28065
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Mouse,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 261 and 323 of Human AKR1C3
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 40% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545541
产品详细信息
Recommended positive controls: HepG2, HeLa, AKR1C3shRNA-transfected HeLa, rat liver.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
AKR1C3 a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 17beta-HSD5; 2-dih; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; Aldo-keto reductase family 1 member C18; Aldo-keto reductase family 1 member C3; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); Chlordecone reductase homolog HAKRb; DD-3; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; dihydrodiol dehydrogenase X; HA1753; HSD1; indanol dehydrogenase; PGFS; Prostaglandin F synthase; Testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase
基因别名: Akr1c18; AKR1C3; DD3; DDH1; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; KIAA0119; PGFS
UniProt ID: (Human) P42330, (Rat) P51652
Entrez Gene ID: (Human) 8644, (Rat) 171516
retinal dehydrogenase activity
alditol:NADP+ 1-oxidoreductase activity
aldo-keto reductase (NADP) activity
retinol dehydrogenase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
dihydrotestosterone 17-beta-dehydrogenase activity
prostaglandin H2 endoperoxidase reductase activity
prostaglandin D2 11-ketoreductase activity
geranylgeranyl reductase activity
ketoreductase activity
prostaglandin-F synthase activity
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
androsterone dehydrogenase activity
testosterone dehydrogenase (NAD+) activity
testosterone 17-beta-dehydrogenase (NADP+) activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity
delta4-3-oxosteroid 5beta-reductase activity
NADP-retinol dehydrogenase activity
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
oxidoreductase
reductase
metabolite interconversion enzyme
protein import into nucleus, translocation
retinoid metabolic process
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
response to nutrient
steroid metabolic process
positive regulation of cell proliferation
male gonad development
cellular response to starvation
positive regulation of cell death
farnesol catabolic process
cyclooxygenase pathway
keratinocyte differentiation
cellular response to reactive oxygen species
progesterone metabolic process
retinol metabolic process
retinal metabolic process
multicellular organismal macromolecule metabolic process
daunorubicin metabolic process
doxorubicin metabolic process
regulation of retinoic acid receptor signaling pathway
positive regulation of protein kinase B signaling
oxidation-reduction process
testosterone biosynthetic process
renal absorption
cellular response to cadmium ion
cellular response to calcium ion
cellular response to prostaglandin stimulus
cellular response to corticosteroid stimulus
cellular response to jasmonic acid stimulus
cellular response to prostaglandin D stimulus
negative regulation of retinoic acid biosynthetic process
regulation of testosterone biosynthetic process
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
progesterone catabolic process
parturition
regulation of steroid biosynthetic process
