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产品信息
H00000208-M02
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1B4
抗原
AKT2 (AAA58364, 100 a.a. approximately 189 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MRAIQMVANS LKQRAPGEDP MDYKCGSPSD SSTTEEMEVA VSKARAKVTM NDFDYLKLLG KGTFGKVILV REKATGRYYA MKILRKEVII
靶标信息
AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AKT2 kinase; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; RAC protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2
基因别名: 2410016A19Rik; AKT2; AW554154; HIHGHH; PKB; PKBB; PKBBETA; PRKBB; RAC-BETA
UniProt ID: (Human) P31751, (Rat) P47197, (Mouse) Q60823
Entrez Gene ID: (Human) 208, (Rat) 25233, (Mouse) 11652
protein serine/threonine kinase activity
protein kinase C binding
protein binding
ATP binding
protein kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
positive regulation of protein phosphorylation
glycogen biosynthetic process
glucose metabolic process
regulation of translation
cellular protein modification process
apoptotic process
response to osmotic stress
signal transduction
insulin receptor signaling pathway
carbohydrate transport
positive regulation of signal transduction
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of glucose metabolic process
response to muscle activity
peptidyl-serine phosphorylation
regulation of cell migration
positive regulation of cell migration
positive regulation of vesicle fusion
response to nutrient levels
positive regulation of fatty acid beta-oxidation
peripheral nervous system myelin maintenance
cellular response to insulin stimulus
negative regulation of RNA splicing
positive regulation of peptidyl-serine phosphorylation
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
positive regulation of glycogen biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
positive regulation of positive chemotaxis
mammary gland epithelial cell differentiation
intracellular protein transmembrane transport
regulation of cell cycle arrest
cellular response to organic cyclic compound
protein localization to plasma membrane
positive regulation of protein targeting to membrane
activation of GTPase activity
positive regulation of cell motility
positive regulation of glucose import in response to insulin stimulus
protein phosphorylation
multicellular organism development
positive regulation of gene expression
positive regulation of sodium ion transport
response to insulin
cellular response to hormone stimulus
negative regulation of apoptotic process
carbohydrate metabolic process
glycogen metabolic process
transport
phosphorylation
