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产品信息
PA5-117779
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived Human ALDH1A2 fragment
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7
内含物
0.03% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2902390
靶标信息
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AL1A2; aldehyde dehydrogenase 1 family, member A2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; RALDH 2; RALDH(II); Retinal dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2
基因别名: ALDH1A2; RALDH(II); RALDH2; RALDH2-T
UniProt ID: (Human) O94788
Entrez Gene ID: (Human) 8854
blood vessel development
kidney development
liver development
regulation of endothelial cell proliferation
retinoic acid biosynthetic process
heart morphogenesis
vitamin A metabolic process
midgut development
positive regulation of cell proliferation
negative regulation of cell proliferation
determination of bilateral symmetry
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of gene expression
neural crest cell development
morphogenesis of embryonic epithelium
neural tube development
pituitary gland development
neuron differentiation
lung development
hindbrain development
pancreas development
embryonic camera-type eye development
response to estradiol
response to vitamin A
response to cytokine
embryonic forelimb morphogenesis
ureter maturation
retinol metabolic process
retinoic acid metabolic process
retinal metabolic process
9-cis-retinoic acid biosynthetic process
positive regulation of apoptotic process
retinoic acid receptor signaling pathway
embryonic digestive tract development
cardiac muscle tissue development
oxidation-reduction process
face development
cellular response to retinoic acid
