Invitrogen

ALG5 Polyclonal Antibody

ALG5 Antibody in Immunocytochemistry (ICC/IF)

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ALG5 Antibody (PA5-109380) in ICC/IF

Immunofluorescence analysis of ALG5 in L929 cells. Samples were incubated with ALG5 Polyclonal antibody (Product # PA5-109380) using a dilution of 1:100. Blue: DAPI for nuclear staining.

ALG5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-109380

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 34-190 of human ALG5 (NP_037470.1).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.68 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2854791

产品详细信息

Immunogen sequence: MPALHRHEEE KFFLNAKGQK ETLPSIWDSP TKQLSVVVPS YNEEKRLPVM MDEALSYLEK RQKRDPAFTY EVIVVDDGSK DQTSKVAFKY CQKYGSDKVR VITLVKNRGK GGAIRMGIFS SRGEKILMAD ADGATKFPDV EKLEKGLNDL QPWPNQM

靶标信息

Dolichyl-phosphate beta-glucosyltransferase (ALG5), belongs to the family of glycosyltransferases, specifically the hexosyltransferases. ALG5 is widely expressed in pancreas, placenta, liver, heart, brain, kidney, skeletal muscle, and lung. ALG5 can catalyze the chemical reaction between UDP-glucose and UDP with dolichyl phosphate.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Monoallelic pathogenic ALG5 variants cause atypical polycystic kidney disease and interstitial fibrosis.

American journal of human genetics

Lemoine H,Raud L,Foulquier F,Sayer JA,Lambert B,Olinger E,Lefèvre S,Knebelmann B,Harris PC,Trouvé P,Desprès A,Duneau G,Matignon M,Poyet A,Jourde-Chiche N,Guerrot D,Lemoine S,Seret G,Barroso-Gil M,Bingham C,Gilbert R,Le Meur Y,Audrézet MP,Cornec-Le Gall E

PA5-109380 was used in Western Blotting to indicate that monoallelic variants of ALG5 lead to a disorder of the ADPKD-spectrum characterized by multiple small kidney cysts, progressive interstitial fibrosis, and kidney function decline.

Thu Aug 04 00:00:00 UTC 2022

生物信息学

蛋白别名: Alg5 homolog; Alg5, S. cerevisiae, homolog of; asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase); asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase); asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog; Asparagine-linked glycosylation protein 5 homolog; dolichyl phosphate glucosyltransferase; Dolichyl-phosphate beta-glucosyltransferase; DolP-glucosyltransferase

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基因别名: 1500026A19Rik; 2600005J22Rik; ALG5; AV009521; AV170001; AW545564; bA421P11.2; HSPC149

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UniProt ID: (Human) Q9Y673, (Mouse) Q9DB25

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Entrez Gene ID: (Human) 29880, (Mouse) 66248, (Rat) 295051

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功能

dolichyl-phosphate-mannose-protein mannosyltransferase activity oligosaccharyl transferase activity dolichyl-phosphate beta-glucosyltransferase activity dolichyl-phosphate beta-D-mannosyltransferase activity transferase activity transferase activity, transferring glycosyl groups glycosyltransferase

参与通路

protein glycosylation protein N-linked glycosylation GPI anchor biosynthetic process determination of left/right symmetry protein N-linked glycosylation via asparagine dolichol metabolic process protein O-linked mannosylation metabolic process