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ALOX12B Antibody (PA5-116671) in WB
Western blot analysis of ALOX12B in extracts of various cell lines. Samples were incubated with ALOX12B Polyclonal antibody (Product # PA5-116671) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-116671
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALOX12B (NP_0011301)
偶联物
Unconjugated
形式
Liquid
浓度
2.7 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2901302
产品详细信息
Positive Samples: A-431, Mouse spleen, Rat testis
Immunogen sequence: MATYKVRVAT GTDLLSGTRD SISLTIVGTQ GESHKQLLNH FGRDFATGAV GQYTVQCPQD LGELIIIRLH KERYAFFPKD PWYCNYVQIC APNGRIYHFP AYQWMDGYET LALREATGKT TADDSLPVLL EHRKEEIRAK QDFYHWRVFL PGLPSYVHIP SYRPPVRRHR NPNRPEWNGY IPGFPILINF KATKFLNLNL RYSFLKTASF FVRLGPMALA FKVRGLLDCK HSWKRLKDIR KIFPGKKSVV
靶标信息
This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 12R-lipoxygenase; 12R-LOX; alox12b {ECO:0000312|RGD:1305330}; Arachidonate 12-lipoxygenase, 12R-type; e-LOX 2; Epidermis-type lipoxygenase 12; Epidermis-type lipoxygenase 2
基因别名: 12R-LOX; ALOX12B; Aloxe2; ARCI2; e-LOX2
UniProt ID: (Human) O75342, (Mouse) O70582, (Rat) Q2KMM4
Entrez Gene ID: (Human) 242, (Mouse) 11686, (Rat) 287425
arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
linoleate 9S-lipoxygenase activity
oxidoreductase activity
2,3-dihydroxy DDT 1,2-dioxygenase activity
phenanthrene dioxygenase activity
2,2',3-trihydroxybiphenyl dioxygenase activity
1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
protocatechuate 3,4-dioxygenase type II activity
2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity
2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
carbazole 1,9a-dioxygenase activity
dihydroxydibenzothiophene dioxygenase activity
1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
styrene dioxygenase activity
3,4-dihydroxyphenanthrene dioxygenase activity
hydroquinone 1,2-dioxygenase activity
p-cumate 2,3-dioxygenase activity
2,3-dihydroxy-p-cumate dioxygenase activity
3,5-dichlorocatechol 1,2-dioxygenase activity
2-aminophenol 1,6-dioxygenase activity
2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
chlorocatechol 1,2-dioxygenase activity
catechol dioxygenase activity
dihydroxyfluorene dioxygenase activity
5-aminosalicylate dioxygenase activity
3-hydroxy-2-naphthoate 2,3-dioxygenase activity
benzo(a)pyrene 11,12-dioxygenase activity
benzo(a)pyrene 4,5-dioxygenase activity
4,5-dihydroxybenzo(a)pyrene dioxygenase activity
benzo(a)pyrene 9,10-dioxygenase activity
9,10-dihydroxybenzo(a)pyrene dioxygenase activity
benzo(a)pyrene 7,8-dioxygenase activity
7,8-dihydroxy benzo(a)pyrene dioxygenase activity
1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
2-mercaptobenzothiazole dioxygenase activity
pyridine-3,4-diol dioxygenase activity
pyrene dioxygenase activity
4,5-dihydroxypyrene dioxygenase activity
phenanthrene-4-carboxylate dioxygenase activity
tetrachlorobenzene dioxygenase activity
4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
2,3-dihydroxydiphenyl ether dioxygenase activity
diphenyl ether 1,2-dioxygenase activity
arachidonate 8(S)-lipoxygenase activity
metal ion binding
4-hydroxycatechol 1,2-dioxygenase activity
dioxygenase activity
molecular_function
oxygenase
protein lipidation
sphingolipid metabolic process
positive regulation of gene expression
arachidonic acid metabolic process
lipoxygenase pathway
positive regulation of MAPK cascade
linoleic acid metabolic process
ceramide biosynthetic process
hepoxilin biosynthetic process
oxidation-reduction process
establishment of skin barrier
positive regulation of mucus secretion
lipid metabolic process
fatty acid metabolic process
bicellular tight junction assembly
biological_process
