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Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Amer2; APC membrane recruitment protein 2; family with sequence similarity 123A; Protein FAM123A
基因别名: AMER2; FAM123A
UniProt ID: (Human) Q8N7J2
Entrez Gene ID: (Human) 219287