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产品信息
38-4200
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from the N-terminal region of the human AMPK-gamma-2 (5'-AMP-activated protein kinase, gamma-2subunit, PRKAG2) protein, which differs from mouse by one amino acid.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2533369
靶标信息
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-AMP-activated protein kinase subunit gamma-2; 5-AMP-activated protein kinase, gamma-2 subunit; ampk gamma; AMPK gamma-2 chain; AMPK gamma2; AMPK subunit gamma-2; H91620p; OTTHUMP00000211956; protein kinase, AMP-activated, gamma 2 non-catalytic subunit
基因别名: 2410051C13Rik; AAKG; AAKG2; AI854673; CMH6; H91620p; PRKAG2; WPWS
UniProt ID: (Human) Q9UGJ0, (Mouse) Q91WG5
Entrez Gene ID: (Human) 51422, (Mouse) 108099
AMP-activated protein kinase activity
cAMP-dependent protein kinase inhibitor activity
ATP binding
cAMP-dependent protein kinase regulator activity
phosphorylase kinase regulator activity
AMP binding
protein kinase binding
protein kinase activator activity
ADP binding
nucleotide binding
kinase modulator
glycogen metabolic process
regulation of glycolytic process
protein phosphorylation
negative regulation of protein kinase activity
fatty acid biosynthetic process
ATP biosynthetic process
carnitine shuttle
cell cycle arrest
positive regulation of peptidyl-threonine phosphorylation
sterol biosynthetic process
macroautophagy
regulation of fatty acid metabolic process
activation of protein kinase activity
intracellular signal transduction
regulation of fatty acid biosynthetic process
positive regulation of protein kinase activity
regulation of fatty acid oxidation
regulation of glucose import
negative regulation of protein serine/threonine kinase activity
regulation of signal transduction by p53 class mediator
lipid metabolic process
fatty acid metabolic process
regulation of catalytic activity
