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APOBEC3G Antibody (H00060489-B01P) in WB
Western Blot analysis of APOBEC3G expression in transfected 293T cell line (H00060489-T03) by APOBEC3G MaxPab polyclonal antibody.
Lane 1: APOBEC3G transfected lysate(42.24 KDa).
Lane 2: Non-transfected lysate.
Lane 1: APOBEC3G transfected lysate(42.24 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00060489-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
APOBEC3G (AAH24268.1, 1 a.a. approximately 384 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MKPHFRNTVE RMYRDTFSYN FYNRPILSRR NTVWLCYEVK TKGPSRPPLD AKIFRGQVYS ELKYHPEMRF FHWFSKWRKL HRDQEYEVTW YISWSPCTKC TRDMATFLAE DPKVTLTIFV ARLYYFWDPD YQEALRSLCQ KRDGPRATMK IMNYDEFQHC WSKFVYSQRE LFEPWNNLPK YYILLHIMLG EILRHSMDPP TFTFNFNNEP WVRGRHETYL CYEVERMHND TWVLLNQRRG FLCNQAPHKH GFLEGRHAEL CFLDVIPFWK LDLDQDYRVT CFTSWSPCFS CAQEMAKFIS KNKHVSLCIF TARIYDDQGR CQEGLRTLAE AGAKISIMTY SEFKHCWDTF VDHQGCPFQP WDGLDEHSQD LSGRLRAILQ NQEN
靶标信息
The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5-a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A3G; APOBEC-related cytidine deaminase; APOBEC-related protein; APOBEC-related protein 9; apolipoprotein B editing enzyme catalytic polypeptide-like 3G; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G; ARP-9; ASGP-R2; ASGPR2; CEM-15; CEM15; CLEC4H2; Deoxycytidine deaminase; DNA dC->dU editing enzyme; DNA dC->dU-editing enzyme APOBEC-3G; FLJ12740; HBXBP; OTTHUMP00000028911; phorbolin-like protein MDS019
基因别名: A3G; APOBEC3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15; CEM15; dJ494G10.1; MDS019
UniProt ID: (Human) Q9HC16
Entrez Gene ID: (Human) 60489
positive regulation of defense response to virus by host
cytidine deamination
negative regulation of transposition
base conversion or substitution editing
negative regulation of viral genome replication
innate immune response
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of viral process
defense response to virus
DNA cytosine deamination
