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产品信息
PA5-89318
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 244-257 of human APOBEC3G (NP_0685941)
偶联物
形式
Liquid
浓度
2.76 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805489
产品详细信息
Positive Samples: Cellular Location: Cytoplasm, Nucleus, P-body
Immunogen sequence: NQAPHKHGFL EGRH
靶标信息
The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5-a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A3G; APOBEC-related cytidine deaminase; APOBEC-related protein; APOBEC-related protein 9; apolipoprotein B editing complex 3; apolipoprotein B editing enzyme catalytic polypeptide-like 3G; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; Apolipoprotein B mRNA-editing complex 3; apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G; ARP-9; Arp3; ASGP-R2; ASGPR2; CEM-15; CEM15; CLEC4H2; Deoxycytidine deaminase; DNA dC->dU editing enzyme; DNA dC->dU-editing enzyme APOBEC-3; DNA dC->dU-editing enzyme APOBEC-3G; FLJ12740; HBXBP; OTTHUMP00000028911; phorbolin-like protein MDS019; recovery from Friend virus 3
基因别名: A3G; Apobec3; APOBEC3G; ARCD; ARP-9; Arp3; ARP9; BC003314; bK150C2.7; CEM-15; CEM15; dJ494G10.1; MDS019; Rfv3
UniProt ID: (Human) Q9HC16, (Mouse) Q99J72
Entrez Gene ID: (Human) 60489, (Mouse) 80287
RNA binding
cytidine deaminase activity
protein binding
zinc ion binding
dCTP deaminase activity
protein homodimerization activity
deoxycytidine deaminase activity
catalytic activity
GTP cyclohydrolase activity
tRNA-specific adenosine deaminase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
N-cyclopropylmelamine deaminase activity
N-cyclopropylammeline deaminase activity
N-cyclopropylammelide alkylamino hydrolase activity
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
tRNA-specific adenosine-37 deaminase activity
archaeal-specific GTP cyclohydrolase activity
poly(A) RNA binding
metal ion binding
tRNA-specific adenosine-34 deaminase activity
RNA processing factor
positive regulation of defense response to virus by host
cytidine deamination
negative regulation of transposition
base conversion or substitution editing
negative regulation of viral genome replication
innate immune response
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of viral process
defense response to virus
DNA cytosine deamination
hematopoietic progenitor cell differentiation
immune system process
metabolic process
