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产品信息
PA5-29861
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 197 of Human NOL3
偶联物
形式
Liquid
浓度
1.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547335
产品详细信息
Recommended positive controls: HeLa.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. ARC inhibits extrinsic apoptotic pathways two different ways. The first is by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. The second way is by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, which in turn limits the amount of soluble CASP8 avaliable for DISC-mediated activation. ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX. This results in BAX inactivation and prevents mitochondrial dysfunction and release of pro-apoptotic factors. Mutations affecting the gene can results in myoclonus, familiam cortical.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apoptosis repressor with CARD; Muscle-enriched cytoplasmic protein; Myp; Nop 30; Nop30; Nucleolar protein 3; nucleolar protein 3 (apoptosis repressor with CARD domain); Nucleolar protein of 30 kDa
基因别名: ARC; B430311C09Rik; FCM; MYC; MYP; NOL3; NOP; NOP30
UniProt ID: (Human) O60936, (Rat) Q62881, (Mouse) Q9D1X0
Entrez Gene ID: (Human) 8996, (Rat) 85383, (Mouse) 78688
response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
mRNA processing
RNA splicing
regulation of gene expression
cardiac muscle cell apoptotic process
negative regulation of striated muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
myoblast differentiation
smooth muscle cell proliferation
protein oligomerization
negative regulation of cytosolic calcium ion concentration
negative regulation of mitochondrial calcium ion concentration
cellular response to hypoxia
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of death-inducing signaling complex assembly
negative regulation of hydrogen peroxide-induced cell death
negative regulation of protein targeting to mitochondrion
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
regulation of NF-kappaB import into nucleus
negative regulation of necrotic cell death
