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产品信息
MA5-32465
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JJ09-01
抗原
Recombinant protein within Human ARID1A aa 1,184-1,334
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809742
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARID domain-containing protein 1A; AT rich interactive domain 1A (SWI-like); AT rich interactive domain 1A (Swi1 like); AT-rich interactive domain-containing protein 1A; B120; BAF250; BAF250A; brain protein 120; BRG1-associated factor 250; BRG1-associated factor 250a; chromatin remodeling factor p250; h BM029; hELD; hOSA1; Osa homolog 1; OSA1 nuclear protein; SWI-like protein; SWI-SNF complex protein p270; SWI/SNF complex protein p270; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; Swi1 like
基因别名: 1110030E03Rik; ARID1A; B120; BAF250; BAF250A; BM029; C1orf4; CSS2; ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1
UniProt ID: (Human) O14497, (Mouse) A2BH40
Entrez Gene ID: (Human) 8289, (Mouse) 93760, (Rat) 297867
negative regulation of transcription from RNA polymerase II promoter
neural tube closure
cardiac chamber development
optic cup formation involved in camera-type eye development
chromatin organization
nucleosome disassembly
chromatin remodeling
maintenance of chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
nervous system development
chromatin modification
intracellular estrogen receptor signaling pathway
androgen receptor signaling pathway
forebrain development
glucocorticoid receptor signaling pathway
ATP-dependent chromatin remodeling
positive regulation of transcription, DNA-templated
cardiac muscle cell differentiation
placenta blood vessel development
toxin transport
biological_process
regulation of transcription from RNA polymerase II promoter
covalent chromatin modification
nucleosome mobilization
chromatin-mediated maintenance of transcription
