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AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ah receptor nuclear translocator; Arnt; ARNT 2; ARNT protein 2; ARNT2A; ARNT2b; ARNT2c; Aryl hydrocarbon receptor nuclear translocator 2; unm t30256; unm_t30256
基因别名: Arnt; arnt2; arnt2a; arnt2X; chunp6921; zfARNT2; zfARNT2a; zfARNT2b; zfARNT2c
UniProt ID: (Zebrafish) Q9DG12
Entrez Gene ID: (Zebrafish) 64277