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Immunogen sequence: VIDDESDYFA SDSNQWLSKL ERETLQKREE ELRELRHASR LSKKVTIDFA GRKILEEENS LAEYHSRLDE TIQAIANGTL NQPLTKLDRS SEEPLGVLVN PNMYQSPPQW VDHTGAASQK KAFRSSGFGL EFNSFQHQLR IQDQEFQEGF DGGWCLSVHQ PWASLLVRGI KRVEGRSWYT PHRGRLWIAA TAKKPSPQEV SELQATYRLL RGKDVEFPND YPSGCLLGCV DLIDCLSQKQ FKEQFPDISQ ESDSPFVFIC KNPQEMVVKF PIKGNPKIWK LDSKIHQGAK KGLMKQNKAV; Positive Samples: A-549, HeLa, LO2, Mouse liver, Mouse testis, Mouse brain, Rat testis, Rat brain; Cellular Location: Cytoplasm, Nucleus, centrosome, cytoskeleton, cytosol, microtubule organizing center
Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Activating signal cointegrator 1; ASC-1; Thyroid receptor-interacting protein 4; TR-interacting protein 4; transcription coactivator Asc1; TRIP-4; zinc finger, C2HC5-type
基因别名: 4930558E03Rik; ASC-1; ASC1; BB191711; HsT17391; RQT4; SMABF1; TRIP4; ZC2HC5
UniProt ID: (Human) Q15650, (Mouse) Q9QXN3
Entrez Gene ID: (Human) 9325, (Rat) 315769, (Mouse) 56404
分子生物学功能:
transcription cofactor
gene-specific transcriptional regulator