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This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Activating signal cointegrator 1 complex subunit 1; ASC-1 complex subunit P50; Trip4 complex subunit p50
基因别名: 1810015P09Rik; AI550520; ASC1p50; ASCC1; CGI-18; p50; SMABF2
UniProt ID: (Human) Q8N9N2, (Mouse) Q9D8Z1
Entrez Gene ID: (Human) 51008, (Mouse) 69090