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Alomone Labs, LTD
ASIC3 Polyclonal Antibody
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FIGURE: 1 / 3
ASIC3 Antibody (ASC-018-GP200UL) in IHC (F)
Expression of ASIC3 in mouse dorsal raphe nucleus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Guinea pig Anti-ASIC3 Antibody (#ASC-018-GP), (1:200), followed by goat- Anti-guinea pig-AlexaFluor-488 secondary Antibody . ASIC3 staining (green) appears in the soma of dorsal raphe nucleus (DRN) neurons (arrows). Nuclei are stained with DAPI (blue).
Product Details
ASC-018-GP200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KPRSGLEEAQRRQAS(C), corresponding to amino acid residues 2-16 of rat ASIC3, Intracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acid sensing ion channel 3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; ASIC3; Dorsal root ASIC; DRASIC; hASIC3; proton gated cation channel DRASIC
Gene Aliases: Accn3; Asic3; AW742291; DRASIC; SLNAC1; TNAC1
UniProt ID: (Mouse) Q6X1Y6, (Rat) O35240
Entrez Gene ID: (Mouse) 171209, (Rat) 286920
transport
ion transport
cation transport
sodium ion transport
response to heat
response to mechanical stimulus
response to acidic pH
ion transmembrane transport
sodium ion transmembrane transport
enterobactin transport
detection of chemical stimulus involved in sensory perception
sensory perception of sour taste
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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