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ASIC3 Antibody (ASC-018-GP200UL) in IHC (F)
Expression of ASIC3 in mouse dorsal raphe nucleus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Guinea pig Anti-ASIC3 Antibody (#ASC-018-GP), (1:200), followed by goat- Anti-guinea pig-AlexaFluor-488 secondary Antibody . ASIC3 staining (green) appears in the soma of dorsal raphe nucleus (DRN) neurons (arrows). Nuclei are stained with DAPI (blue).
产品信息
ASC-018-GP200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KPRSGLEEAQRRQAS(C), corresponding to amino acid residues 2-16 of rat ASIC3, Intracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acid sensing ion channel 3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; ASIC3; Dorsal root ASIC; DRASIC; hASIC3; proton gated cation channel DRASIC
基因别名: Accn3; Asic3; AW742291; DRASIC; SLNAC1; TNAC1
UniProt ID: (Mouse) Q6X1Y6, (Rat) O35240
Entrez Gene ID: (Mouse) 171209, (Rat) 286920
transport
ion transport
cation transport
sodium ion transport
response to heat
response to mechanical stimulus
response to acidic pH
ion transmembrane transport
sodium ion transmembrane transport
enterobactin transport
detection of chemical stimulus involved in sensory perception
sensory perception of sour taste
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception
cation transmembrane transport
